...Howard W. Bruckner; Jill Kalman; Melvin Spigelman; Mayer I. Gorbaty; Nina Butwell; Jody Storch; Anne McKenna Hexamethylmelamine, mitomycin C and 5-fluorouracil infusion (HexMF) achieved a median survival of 9 months for the 45 patients with either metastatic stage III or unresectable stage II...

...D.V. Razis; E. Poulakou; A. Petounis; G. Papadimitriou; P. Kosmides; G. Delides During the last 2½ years, 38 patients with ovarian cancer were treated with a combination of cis-platinum (CPDD), 50 mg/m 2 , adriamycin, 30 mg/m 2 , cyclophosphamide, 300 mg/m 2 , on day 1; and hexamethylmelamine (HMM...

...Howard W. Bruckner; Jody A. Storch; John C. Brown; Judith Goldberg; Karen Chamberlin A combination consisting of hexamethylmelamine 150 mg/m 2 D2–15, mitomycin C 10 mg/m 2 D2 and 5-fluorouracil 30 mg/kg/day as a continuous infusion for 5 days, in 4–5 week cycles, underwent phase II trial as primary...

...Howard W. Bruckner; Jody A. Storch; John C. Brown; Judith Goldberg; Karen Chamberlin HexMF consists of hexamethylmelamine 150 mg/m 2 D2–15, mitomycin C (MMC) 10 mg/m 2 D2 and 5-fluorouracil (5-FU) 30 mg/kg/day as a continuous infusion Dl-5 in 4–5 week cycles. It was designed as an alternative...

...Nicholas J. DiBella; Roald A. Nelson; Michael J. Norgard 18 patients with metastatic or recurrent bronchogenic carcinoma and one patient with a squamous cell carcinoma of the trachea were treated with a combination of CCNU, hexamethylmelamine and methotrexate. Objective remissions were observed...

...W.L. Wilson; J. Van Ryzin; A.J. Weiss; R.W. Frelick; S.E. Moss A phase III study was designed comparing the effectiveness of Hexamethylmelamine (NSC 13875) to Dibromodulcitol (NSC 104800) in lung carcinoma. 250 of the 316 patients entered on the study were stratified into groups according to stage...

...M.N. Huang; H. Takita; H. Catane; Yee Chen Hexamethylmelamine (HXM) is one of the substituted melamines derived from cyanuric chloride [1]. Previous studies with HXM have shown activity against small cell carcinoma of the lung, when it was given as a single agent [2, 3]. Because of relatively mild...