...) with folinic acid (FA) resulted in an improved response rate and survival in the responder patients. Preclinical studies also showed an enhancement of FU and anthracyclines with interferon. To evaluate the possibility of human lymphoblastoid interferon (IFN) to enhance the therapeutic activity of the FA-FU...

...C.H. KÖhne; H. Wilke; W. Hiddemann; C. Bokemeyer; H.P. Lohrmann; H. Bodenstein; J. Preiss; H. Rauschecker; H. Hill; C. Käufer; J.Th. Fischer; U. Ohl; D. Urbanitz; L. Balleisen; H.J. Schmoll Biochemical modulation of 5-fluorouracil (5-FU) by folinic acid (FA) increases the response rate in patients...

... employing weekly 5-fluorouracil (FU) 350 mg/m 2 , folinic acid (FA) 500 mg/m 2 , and epirubicin (EPI) 35 mg/m 2 , for a maximum of 18 cycles. Twenty-three patients were evaluable for response. One achieved a complete response and 7 showed a partial response, for an objective response rate of 35%; 7 (31...

... following the two cycles of chemotherapy. Additionally, all patients received folinic acid 200 mg/m 2 for 5 days as a continuous infusion. None of the nonresponders responded to the addition of folinic acid, on the contrary toxicity was increased and 2 toxic deaths were reported. We conclude that continuous...

...Werner Scheithauer; Dieter Depisch; Rudolf Schiessel; Heinz Ludwig Twenty-seven patients with advanced measurable colorectal carinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m 2 i.v. bolus followed by 5-fiuorouracil (5-FU) 550 mg/m 2 , and cisplatin (CIS) 20...

...G. Marini; E. Simoncini; A. Zaniboni; F. Gorni; P. Marpicati; A. Zambruni We report an update of our results of a trial of high-dose folinic acid (HDFA) and 5-fiuorouracil (5-FU) in advanced breast cancer. Thirty-eight patients with advanced and mainly refractory breast cancer were treated...

... and moderate toxicity indicate the need for further study of this regimen in the treatment of gynecologic malignancies. Methotrexate Chemotherapy Leucovorin Folinic acid Rescue Gynecologic malignancy Cervical malignancy © 1975 S. Karger AG, Basel 1975 Copyright / Drug Dosage / Disclaimer...

...A. Wein; C. Riedel; W. Brückl; S. Merkel; R. Ott; B. Hanke; U. Baum; F. Fuchs; K. Günther; T. Reck; T. Papadopoulos; E.G. Hahn; W. Hohenberger Purpose: To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid...

...C. Carlomagno; R. Lauria; M. De Laurentiis; G. Arpino; E. Massarelli; C. Ferrara; A. Milano; A. Vernaglia Lombardi; R. Costanzo; G. Catalano; A.R. Bianco; S. De Placido Background and Aim: In vitro, methotrexate (MTX) is the best modulator for bolus 5-fluorouracil (5FU), whereas folinic acid (FA...

... of gemcitabine, fluorouracil (5-FU) and folinic acid (leucovorin, LFA) in metastatic breast cancer patients pretreated with anthracyclines and taxanes. Methods: Metastatic breast cancer patients aged ≤75 years, with ECOG performance status 0–2, were eligible, provided that they had received previous...

... with folinic acid plus mitomycin C in patients with advanced gastric cancer. Patients and Methods: Chemonaive patients with locally advanced inoperable, recurrent or metastatic gastric cancer were treated with 15 mg/m 2 i.v. mitomycin C as bolus on day 1 of a 7-week cycle followed by a 2-hour infusion...

...M. Lorenz; E. Staib-Sebler; C. Gog; H. Petrowsky; C.H. Köhne; A. Encke Purpose: A pilot study was performed to evaluate the tolerance and efficacy of a hepatic arterial infusion (HAI) of 5-fluorouracil (5-FU) and folinic acid (FA) in patients with unresectable liver metastases from colorectal...