... lung cancer (NSCLC), the impact of first-line treatment on overall survival (OS) may be influenced by subsequent therapies. Thus, using patient-level data, we assessed the relationships of progression-free survival (PFS) and post-progression survival (PPS) with OS among patients with high-programmed...

... cerebral lobes. Previous studies in gliomas found no distinct histological or molecular GC subtype, yet the presence of GC is associated with worse median overall survival (OS). Here, we explored whether differing therapeutic strategies in first-line treatment could account for this. Methods: From our...

... with targeted agents that are approved for first-line treatment of metastatic renal cell carcinoma and considers the reasons for switching or discontinuing therapy. In addition, practical strategies for achieving optimal treatment duration, through adverse event management, are discussed. Median duration...

... to in the content or advertisements. Metastatic breast cancer Paclitaxel Epirubicin Cyclophosphamide First-line treatment Metastatic breast cancer is an incurable disease. Despite clinical responses of 44–57% achieved with standard combination regimens comprising 5-fluorouracil, an anthracycline...