...Orly Yariv; Raz Mutai; Ofer Rotem; Daliah Tsoref; Yasmin Korzets; Assaf Moore; Tzippy Shochat; Rinat Yerushalmi; Hadar Goldvaser Introduction: The impact of exogenous estrogen exposure on breast cancer characteristics and outcomes is not well described. We aimed to investigate the effect of prior...

...Jessica E. Pritchard; Patrick M. Dillon; Mark R. Conaway; Corinne M. Silva; Sarah J. Parsons Objective: Estrogen treatment limits the cytotoxic effects of chemotherapy in estrogen receptor-positive (ER+) breast cancer cell lines, suggesting that estrogen pathway signaling may confer...

...Shiou-Hwei Yeh; Pei-Jer Chen Men have a higher incidence of hepatocellular carcinoma (HCC) than women. Epidemiologic and animal studies have suggested that it might be due to the stimulatory effects of androgen and the protective effects of estrogen. Recently, increasing molecular mechanisms...

... be noted that estradiol plus macrophages had the most potent antitumor action among them. These results suggest that macrophages, especially estrogen-activated macrophages, may play an important role in antitumor and antitumor-promoting actions of organisms. 30 6 2009 © 1996 S. Karger AG, Basel...

... method has proved itself to be a useful tool in order to assess the cellular heterogeneity of carcinoma cells. 17 6 2009 Mouse mammary tumor Estrogen Actinomycin D binding © 1985 S. Karger AG, Basel 1985 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... with the fastest growing synovial sarcomas were pregnant and, in addition, 2 of them developed mammary adenocarcinomas, indicating that they were rich in estrogen. On the other hand, it is known that Δ 9 -tetrahydrocannabinol causes a decrease in the sex hormone. It is consequently thought that the cannabinoids...

...Kazuo Kubota; Roko Kubota; Taiju Matsuzawa To study why the tumor growth rate was different among host mice of different sexes and ages, we examined the role of sex hormones in the growth and development of mouse teratocarcinoma OTT6050 in vivo. Estrogen and progesterone showed enhancement of tumor...

...R.B. Wallace; B.M. Sherman; J.A. Bean A history of prior total bilateral oophorectomy and exogenous estrogen use was elicited from 45 women with breast surgery for cancer, 19 of whose neoplasms were estrogen receptor (ER) positive and 26 ER negative. In the ER-positive group there was a history...

...J.W. Proctor; Y. Yamamura; D. Gaydos; W. Mastromatteo An intramuscularly inoculated B 16 melanoma line grew more slowly in normal female mice than in either those following oophorectomy and/or estrogen therapy, or in male syngeneic C57BL6J mice following orchidectomy and/or estrogen therapy...

...L. Sadoff; J. Winkley; Sandra Tyson Evidence is submitted suggesting malignant melanoma may be an estrogen-dependent tumor, similar in its behavior to cancer of the breast, kidney and endometrium. Evidence is based largely on case reports showing activation of melanoma following estrogen...

...Anuradha Sharma; Manish S. Sharma; Michelle De Padua; Urvashi P. Jha; Ajaya N. Jha Background: While unopposed estrogen hormone secretion is most commonly implicated in the pathogenesis of endometrial carcinoma, the role of prolactin has only recently been highlighted. The authors present a case...

... birth and breast cancer risk. Int J Cancer 1983;31:701–704. 15. Miettinen OS: Theoretical Epidemiology. New York, Wiley, 1985. 16. Chopra IJ, Tulchinsky D, Greenway FL: Estrogen-androgen imbalance in hepatic cirrhosis. Studies in 13 male patients. Ann Intern Med 1973;79:198–203. 17. Baker HW...

...Yuji Tanaka; Koichiro Kuwabara; Tomoki Okazaki; Toshiro Fujita; Iwao Oizumi; Shin-ichi Kaiho; Etsuro Ogata Estrogen receptor (ER)-positive breast cancers initially respond well to estrogen ablation treatment but finally acquire refractoriness, the phenomenon that is a major clinical problem...

.... In addition, 17β-HSD type 1 coexpression is significantly correlated with estrogen receptor status in invasive ductal carcinoma cases. These results indicate that breast carcinoma can effectively convert E 1 , produced as a result of in situ aromatization, to E 2 , a biologically potent estrogen, and exerts...

.... In MCF-7 cells, estrogen-induced autocrine loop has been demonstrated to play the important role for estrogen-dependent growth. Androgen has been also found to promote the growth of SC-3 cell through the induction of an autocrine growth factor (FGF 8). The blockade of FGF 8 activity resulted...

..., and Raf-1 protein was greater in cancerous human tissues than in the surrounding noncancerous glands. In a 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinoma model, estrogen promoted and ovariectomy and antiestrogen, tamoxifen (TAM) inhibited the tumor growth. Ovariectomy suppressed expression...

...Hiroki Hata; Mieko Hamano; Jun Watanabe; Hiroyuki Kuramoto The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa...