... the expression of these cytokines and the subsequent prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods: A robust clustering algorithm was used, the Gaussian mixture method (GMM), through the mclust R package to group patients based on the expression of their cytokines in plasma...

... to chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC) is a critical challenge. The protein SIRT1, recognized for its implications in longevity, has been associated with tumor promotion in ESCC. However, data regarding its correlation with CRT sensitivity remain unreported. Therefore...

...-fluorouracil (DCF) therapy for resectable advanced esophageal squamous cell carcinoma (ESCC). Methods: Patients diagnosed with resectable advanced ESCC at our hospital between January 2010 and December 2019 underwent either neoadjuvant DCF therapy or DCS therapy, followed by radical esophagectomy. Prior...

... Kinoshita; Takuma Sasaki; Keiko Iida; Aki Komatsu; Hisahiro Matsubara Introduction: Antidiabetic drug metformin exerts various antitumor effects on different cancers. Esophageal squamous cell carcinoma (ESCC) is an intractable digestive organ cancer and new treatment strategy is required. In this study, we...

... is associated with the response to ICIs in patients with recurrent or metastatic esophageal squamous cell carcinoma (ESCC). Methods: Patients with ESCC who had measurable tumors in the liver, lung, or lymph node (LN) according to the response evaluation criteria in solid tumors (RECIST) 1.1 and received ICIs...

... sensitive detection of circulating tumor DNA (ctDNA) in a relatively wide range of genes. Objective: The aim of this study was to examine the utility of NGS with MB for detecting ctDNA in patients with esophageal squamous cell carcinoma (ESCC). Methods: Five patients with ESCC who underwent preoperative...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Esophageal squamous cell carcinoma Neoadjuvant chemotherapy Prognostic factor Surgery Esophageal cancer is the fifth most common cause of cancer-related death in men...

...Quoc Thang Pham; Naohide Oue; Yohei Sekino; Yuji Yamamoto; Yoshinori Shigematsu; Naoya Sakamoto; Kazuhiro Sentani; Naohiro Uraoka; Wataru Yasui Objective: Esophageal cancer is one of the deadliest cancers in the world, and the main subtype is esophageal squamous cell carcinoma (ESCC), which...

... was to investigate the utility of surveillance after definitive chemoradiotherapy (dCRT) in patients with squamous cell carcinoma. Methods: Patients who underwent dCRT for stage II/III (excluding T4) esophageal squamous cell carcinoma were analyzed. First failures following complete response were classified...

...Keishi Yamashita; Kei Hosoda; Hiromitsu Moriya; Chikatoshi Katada; Mitsuhiro Sugawara; Hiroaki Mieno; Shoko Komori; Natsuya Katada; Masahiko Watanabe Background: Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages...

... esophageal squamous cell carcinoma (ESCC) requires reassessment. We have conducted a trial aiming at the comparison between DCF and ACF concerning perioperative adverse events. Methods: Patients were randomly assigned to receive either DCF [docetaxel 70 mg/m 2 , cisplatin 70 mg/m 2 on day 1, and 5...

... glutamate dehydrogenase (GDH). The current study aimed to evaluate the clinical and biological significance of SIRT4 in esophageal squamous cell carcinoma (ESCC). Methods: The study comprised 172 patients with surgically resected ESCC in two independent cohorts. SIRT4 mRNA expression was analyzed in Cohort...

... pathological findings are independent prognostic factors for patients undergoing neoadjuvant chemotherapy for advanced thoracic esophageal SCC. This analysis may aid in stratification according to individual patient risk. Esophageal squamous cell carcinoma Neoadjuvant chemotherapy Prognostic factors...

... of this study was to identify alternative compounds to the tumor suppressor miR-375 using the connectivity map (CMAP) and to validate the antitumor effects of the identified drugs in esophageal squamous cell carcinoma (ESCC). Methods: Gene profiling of miR-375-treated TE2 and T.Tn cells was applied in order...

...Kazuhiro Kaneko; Tomonori Yano; Keiko Minashi; Takashi Kojima; Miki Ito; Hironaga Satake; Yoko Yajima; Yusuke Yoda; Hiroaki Ikematsu; Yasuhiro Oono; Ryuichi Hayashi; Masakatsu Onozawa; Atsushi Ohtsu Background: Esophageal squamous cell carcinoma (ESCC) is often synchronously accompanied...

...Seung Tae Kim; Kyong Hwa Park; Sang Cheul Oh; Jae Hong Seo; Sang Won Shin; Jun Suk Kim; Yeul Hong Kim Despite first-line therapy, most patients with advanced esophageal squamous cell carcinoma (ESCC) experience disease progression and may become eligible for second-line chemotherapy. Although...

... the proliferative activity of cancer cells by immunostaining with the Ki-67 monoclonal antibody in 95 cases of surgically resected esophageal squamous cell carcinoma and compared them with the extent of lymphocytic infiltration of the tumor (LI) in the same specimens. The mean Ki-67 score of 43 tumors with low...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Esophageal squamous cell carcinoma Seprase Dipeptidyl peptidase IV Urokinase-type plasminogen activator Extracellular...

... to in the content or advertisements. p53 Genetherapy Leptomycin B Esophageal squamous cell carcinoma Esophageal cancer is one of the most aggressive malignancies with an overall 5-year survival rate of less than 10% [ 1 ]. Esophagealcancer exists in 2 main forms with distinct etiological...

... of squamous cell carcinoma of the esophagus using tissue quantitative fluorescence in situ hybridization (Q-FISH). We hypothesized that the very rapid cell proliferation observed in esophageal squamous cell carcinomas might accelerate the telomere shortening and chromosomal instability associated...