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1-20 of 53
Keywords: Epidermal growth factor receptor
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Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2024) 102 (11): 969–978.
Published Online: 25 July 2024
... with treatment outcomes of various human malignancies, including lung cancer. However, the clinical implications of this protein in surgically resected lung cancers harboring epidermal growth factor receptor (EGFR) mutations have not been investigated. Methods: Data were collected from patients who underwent...
Journal Articles
Yuki Akazawa, Satoshi Igawa, Kaori Yamada, Hiroki Yamamoto, Yuri Yagami, Nobuki Kaizuka, Hiroya Manaka, Masashi Kasajima, Yoshiro Nakahara, Takashi Sato, Hisashi Mitsufuji, Masanori Yokoba, Masaru Kubota, Jiichiro Sasaki, Katsuhiko Naoki
Journal:
Oncology
Oncology (2023) 101 (11): 685–694.
Published Online: 25 April 2023
...Yuki Akazawa; Satoshi Igawa; Kaori Yamada; Hiroki Yamamoto; Yuri Yagami; Nobuki Kaizuka; Hiroya Manaka; Masashi Kasajima; Yoshiro Nakahara; Takashi Sato; Hisashi Mitsufuji; Masanori Yokoba; Masaru Kubota; Jiichiro Sasaki; Katsuhiko Naoki Introduction: Epidermal growth factor receptor (EGFR...
Journal Articles
Subject Area:
Oncology
Jeng-Sen Tseng, Kuo-Hsuan Hsu, Zhe-Rong Zheng, Tsung-Ying Yang, Kun-Chieh Chen, Yen-Hsiang Huang, Kang-Yi Su, Sung-Liang Yu, Gee-Chen Chang
Journal:
Oncology
Oncology (2021) 99 (1): 32–40.
Published Online: 07 September 2020
...Jeng-Sen Tseng; Kuo-Hsuan Hsu; Zhe-Rong Zheng; Tsung-Ying Yang; Kun-Chieh Chen; Yen-Hsiang Huang; Kang-Yi Su; Sung-Liang Yu; Gee-Chen Chang Objectives: The characteristics and efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in advanced EGFR -mutant lung...
Journal Articles
Subject Area:
Oncology
Stefano Cavalieri, Federica Perrone, Massimo Milione, Alba Bianco, Salvatore Alfieri, Laura D. Locati, Cristiana Bergamini, Carlo Resteghini, Donata Galbiati, Francesca Platini, Lisa Licitra, Paolo Bossi
Journal:
Oncology
Oncology (2019) 97 (2): 112–118.
Published Online: 21 May 2019
... of surgery or irradiation may benefit from systemic therapies. Epidermal growth factor receptor (EGFR) inhibitors and, more recently, immune checkpoint blockers (ICBs) showed activity in R/M sSCC. In this study, we aimed at exploring the possible role of PD-L1 expression in predicting response to anti-EGFR...
Journal Articles
Subject Area:
Oncology
Sook-Hee Hong, Ho jung An, Kihyun Kim, Seung Sei Lee, Yun-Gyoo Lee, Young-Jin Yuh, I Cheon Park, Yee Soo Chae, Tae-Won Jang, Jin-Hyoung Kang
Journal:
Oncology
Oncology (2018) 96 (1): 51–58.
Published Online: 26 October 2018
...Sook-Hee Hong; Ho jung An; Kihyun Kim; Seung Sei Lee; Yun-Gyoo Lee; Young-Jin Yuh; I Cheon Park; Yee Soo Chae; Tae-Won Jang; Jin-Hyoung Kang Objectives: Anti-angiogenic agents are reported to exert clinical activity on epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancers. We...
Journal Articles
Subject Area:
Oncology
Quoc Thang Pham, Naohide Oue, Yohei Sekino, Yuji Yamamoto, Yoshinori Shigematsu, Naoya Sakamoto, Kazuhiro Sentani, Naohiro Uraoka, Wataru Yasui
Journal:
Oncology
Oncology (2018) 95 (5): 297–308.
Published Online: 22 August 2018
.... Knockdown of TDO2 expression also induced inactivation of the epidermal growth factor receptor signaling pathway. Conclusion: Our results imply that TDO2 could play an important role in the progression of ESCC. Furthermore, TDO2 may be a potential therapeutic target in ESCC. Cancer stem cells (CSCs) have...
Journal Articles
Subject Area:
Oncology
Katsuhiro Masago, Kei Irie, Shiro Fujita, Fumiko Imamichi, Yutaka Okada, Nobuyuki Katakami, Shoji Fukushima, Yasushi Yatabe
Journal:
Oncology
Oncology (2018) 95 (4): 251–256.
Published Online: 14 June 2018
...Katsuhiro Masago; Kei Irie; Shiro Fujita; Fumiko Imamichi; Yutaka Okada; Nobuyuki Katakami; Shoji Fukushima; Yasushi Yatabe Purpose: The purpose of the study was to evaluate the site of paronychia in patients with non-small cell lung cancer harboring an epidermal growth factor receptor (EGFR) gene...
Journal Articles
Subject Area:
Oncology
Nathália Kersting, Bárbara Kunzler Souza, Igor Araujo Vieira, Rafael Pereira dos Santos, Danielly Brufatto Olguins, Lauro José Gregianin, André Tesainer Brunetto, Algemir Lunardi Brunetto, Rafael Roesler, Caroline Brunetto de Farias, Gilberto Schwartsmann
Journal:
Oncology
Oncology (2018) 94 (6): 383–393.
Published Online: 14 March 2018
... of childhood cancer probably arising from stem mesenchymal or neural crest cells. The epidermal growth factor receptor (EGFR) acts as a driver oncogene in many types of solid tumors. However, its involvement in ES remains poorly understood. Methods: Human SK-ES-1 and RD-ES ES cells were treated with EGF...
Journal Articles
Subject Area:
Oncology
Young Wha Koh, Han Jo Kim, Hyog Young Kwon, Jae-Ho Han, Chi-Kyou Lee, Moon-Su Lee, Chang-Jin Kim, Moo-Jun Baek, Dongjun Jeong
Journal:
Oncology
Oncology (2016) 90 (5): 289–298.
Published Online: 22 March 2016
... a poor prognosis (p = 0.032). Conclusions: The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II. [email protected] Polymorphism Epidermal growth factor receptor...
Journal Articles
Subject Area:
Oncology
Satoshi Igawa, Masashi Kasajima, Mikiko Ishihara, Michiko Kimura, Yasuhiro Hiyoshi, Maiko Asakuma, Sakiko Otani, Ken Katono, Jiichiro Sasaki, Noriyuki Masuda
Journal:
Oncology
Oncology (2014) 87 (4): 215–223.
Published Online: 15 July 2014
...Satoshi Igawa; Masashi Kasajima; Mikiko Ishihara; Michiko Kimura; Yasuhiro Hiyoshi; Maiko Asakuma; Sakiko Otani; Ken Katono; Jiichiro Sasaki; Noriyuki Masuda Background: Exon 19 deletion and L858R point mutation of the epidermal growth factor receptor (EGFR) are the most commonly encountered EGFR...
Journal Articles
Subject Area:
Oncology
Hiroshi Soeda, Hideki Shimodaira, Makio Gamoh, Hideaki Ando, Hideki Isobe, Takeshi Suto, Shin Takahashi, Yuichi Kakudo, Kenji Amagai, Takahiro Mori, Mika Watanabe, Takuhiro Yamaguchi, Shunsuke Kato, Chikashi Ishioka
Journal:
Oncology
Oncology (2014) 87 (1): 7–20.
Published Online: 24 June 2014
... of response to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy by patients with metastatic colorectal cancer (mCRC). However, it has been based on the study of mainly Caucasian mCRC patients. This prospective study investigated the relationship between the mutation status of EGFR...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2014) 86 (5-6): 263–270.
Published Online: 04 June 2014
...Soichi Oka; Hidetaka Uramoto; Hidehiko Shimokawa; Sohsuke Yamada; Fumihiro Tanaka The overexpression of Arf6 and GEP100 is responsible for the invasive activity that is crucial for the activation of the epidermal growth factor receptor (EGFR) signaling pathways in human cancer. However, whether...
Journal Articles
Subject Area:
Oncology
Jun Fukihara, Naohiro Watanabe, Hiroyuki Taniguchi, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Toshiaki Matsuda, Toshiki Yokoyama, Yoshinori Hasegawa
Journal:
Oncology
Oncology (2014) 86 (2): 86–93.
Published Online: 18 January 2014
...Jun Fukihara; Naohiro Watanabe; Hiroyuki Taniguchi; Yasuhiro Kondoh; Tomoki Kimura; Kensuke Kataoka; Toshiaki Matsuda; Toshiki Yokoyama; Yoshinori Hasegawa Background: The presence of EGFR (epidermal growth factor receptor) mutations is a robust predictor of EGFR tyrosine kinase inhibitor (TKI...
Journal Articles
Subject Area:
Oncology
Aung Naing, Rishi Agarwal, Gerald Falchook, David S. Hong, Filip Janku, Jennifer Wheler, Siqing Fu, Razelle Kurzrock
Journal:
Oncology
Oncology (2013) 85 (6): 350–355.
Published Online: 06 December 2013
... retreated with the same agent(s), 1 with a different agent possessing the same mechanism of action (e.g., in case of an epidermal growth factor receptor inhibitor, using gefitinib first, then erlotinib), and 5 with the same agent(s) in combination with other agents. Conclusion: Our pilot data suggest...
Journal Articles
Subject Area:
Oncology
Domenico Cante, Maria Rosa La Porta, Pierfrancesco Franco, Piera Sciacero, Giuseppe Franco Girelli, Annamaria Marra, Gianmauro Numico, Nerina Denaro, Elvio Grazioso Russi, Umberto Ricardi
Journal:
Oncology
Oncology (2013) 85 (5): 257–261.
Published Online: 29 October 2013
...Domenico Cante; Maria Rosa La Porta; Pierfrancesco Franco; Piera Sciacero; Giuseppe Franco Girelli; Annamaria Marra; Gianmauro Numico; Nerina Denaro; Elvio Grazioso Russi; Umberto Ricardi It is well known that the cetuximab (Cet) epidermal growth factor receptor (EGFR) antibody enhances...
Journal Articles
Subject Area:
Oncology
Renuka Iyer, Ravi Chhatrala, Tracey Shefter, Gary Yang, Usha Malhotra, Wei Tan, Charles LeVea, Melissa Robins, Nikhil Khushalani
Journal:
Oncology
Oncology (2013) 85 (1): 53–58.
Published Online: 10 July 2013
... 1-year survival was 29% (95% CI: 11-51%), 5 patients lived >12 months. Treatment-related toxicities of grade 3-4 occurred in 5 patients. Patients with epidermal growth factor receptor amplification and never smokers had the longest OS (22.3 and 16.6 months, respectively). Conclusions: Erlotinib...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2012) 83 (6): 305–320.
Published Online: 05 September 2012
.... Doxorubicin Breast cancer Estrogen Estrogen receptor Epidermal growth factor receptor National Institutes of Health (NIH) 10.13039/100000002 Breast cancer is the most commonly diagnosed and the second most deadly cancer in women [ 1 ]. Clinically, breast tumors can be classified...
Journal Articles
Subject Area:
Oncology
Zhijie Wang, Xuchao Zhang, Hua Bai, Jun Zhao, Minglei Zhuo, Tongtong An, Jianchun Duan, Lu Yang, Meina Wu, Shuhang Wang, Yuyan Wang, Yilong Wu, Jie Wang
Journal:
Oncology
Oncology (2012) 83 (5): 248–256.
Published Online: 04 September 2012
...) and to investigate possible associations of NSCLC with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) mutations. Methods: Patients with stage IV NSCLC were screened for EML4-ALK rearrangement and EGFR mutations at the Peking...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2012) 82 (3): 175–179.
Published Online: 15 March 2012
...Joshua Peck; Lai Wei; Mark Zalupski; Bert O’Neil; Miguel Villalona Calero; Tanios Bekaii-Saab Purpose: Biliary cancers (BCs) respond poorly to chemotherapy. Lapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and HER2/neu, both implicated in cholangiocarcinogenesis. This trial...
Journal Articles
Subject Area:
Oncology
Robert Königsberg, Wolfgang Hulla, Martin Klimpfinger, Angelika Reiner-Concin, Tanja Steininger, Wilfried Büchler, Robert Terkola, Christian Dittrich
Journal:
Oncology
Oncology (2012) 81 (5-6): 359–364.
Published Online: 13 January 2012
...Robert Königsberg; Wolfgang Hulla; Martin Klimpfinger; Angelika Reiner-Concin; Tanja Steininger; Wilfried Büchler; Robert Terkola; Christian Dittrich Treatment of metastasized colorectal cancer (mCRC) patients with anti-epidermal growth factor receptor (EGFR)-directed monoclonal antibodies...
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