...Chih-Yang Hsiao; Chang-Yi Lu; Hung-Ju Su; Kai-Wen Huang Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Lack of biomarkers for follow-up after treatment is a clinical challenge. DNA methylation has been proposed to be a potential biomarker in HCC. However...

... activation of GNAS and/or KRAS . However, the involvement of global epigenetic alterations in PMPs has not been reported. Methods: To clarify the genetic background of the 15 PMP tumors, we performed genetic analysis using AmpliSeq Cancer HotSpot Panel v2. We further investigated global DNA methylation...

...Bin Xie; Wenyan Dong; Fengping He; Feng Peng; Honghua Zhang; Wei Wang Introduction: The study explored the effects of SHOX2 and RASSF1A DNA methylation in lung cancer (LC). Method: Bronchoalveolar lavage fluid (BALF) samples as well as LC and normal adjacent tissues were collected from 72 LC...

... expression in both cancer types. DNA methylation pattern in SOX2 promoter could not be appreciably counted for SOX2 overexpression. Activation of SOX2 gene promoter was due to very high deposition of H3K4me3 and H3K9acS10p and drastic decrease of H3K9me3 and H3K27me3. Conclusion: Histone modification...

... solvents. Gastric Cancer DNA methylation Diffuse-type gastric cancers Signet-ring cell carcinoma Wnt signal pathway Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide [ 1 ]. Currently, the generalized method for the classification...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CA19-9 DNA methylation HOXA1 Liquid biopsy Pancreatic cancer SST...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Biomarker CA19-9 Digital PCR DNA methylation Pancreatic cancer RUNX3...

... of interference by coexisting noncancer cells in molecular analyses, we aimed to develop a DNA methylation marker that assesses a cancer cell fraction in DNA samples. Methods: The microarray data of 22 pancreatic cancer tissues from the The Cancer Genome Atlas database and 9 noncancer tissues were used for genome...

... DNA methylation Colorectal cancer Prognostic factor Chemoresistance Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world [ 1 ]. Although CRC is generally recognized as a disease largely influenced by demographic factors and environmental exposure [ 2...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatocellular carcinoma Tumor suppressor gene DNA methylation Epigenetics Molecular diagnosis Oncology 2013;84(suppl 1):82 87 DOI: 10.1159...

... and benign controls by using MSP or quantitative DNA methylation analysis [ 31, 33, 36 ]. Similar findings have also been documented in urine sediments from benign controls [ 31, 36, 37 ]. Promoter hypermethylation observed in non-malignant or premalignant urothelium indicate the occurrence of epigenetic...

...Yu-Mei Gu; Jian-Xin Tan; Xiao-Wei Lu; Yun Ding; Xiao Han; Yu-Jie Sun Objective: To investigate the role of DNA methylation in the regulation of BCSG1 gene expression in breast tissues derived from Chinese women with breast cancer. Methods: The methylation status of exon 1 of the BCSG1 gene...

... on ice. RUNX Esophageal cancer Smad DNA methylation Esophageal cancer ranks among the 10 most frequent cancers and is the fifth most common gastrointestinal cancer in the world [ 1 ]. Prognosis of this tumor is dismal, and only 8–20% of patients are alive at 5 years following curative...

..., Sugimura T, Hirohashi S: Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 1995;92:7416–7419. 4. Jones PA: The DNA methylation paradox. Trends Genet 1999;15:34–37. 5. Hohn T, Corsten S, Rieke S, Muller M, Rothnie H: Methylation...

... grade, N grade, tumor stage, or histological type. Our results suggest that transcriptional inactivation of TSP1 by aberrant DNA methylation of the promoter region may participate partly in stomach carcinogenesis through TSP1 down-regulation. In the present study, we measured the expression level...

... these variants play a role in hormone-resistant disease. Additionally, the DNA methylation of the ER gene itself may control ER expression. These epigenetic changes can play an important role in the loss of hormone dependence in breast cancer. 21 12 1998 Estrogen receptor Splicing variant DNA...