..., instructions or products referred to in the content or advertisements. Cancer genomics Copy number alteration Comparative genomic hybridization Bioinformatics Cancers are based on the accumulation of genomic mutations, leading to the transformation of somatic cells into a malignant clone...

... and structural chromosomal aberrations were investigated by comparative genomic hybridization (CGH), and results were compared to those obtained in fresh tumor tissues of the same patients. Results: All cell lines expressed cytokeratins 5/6 and 19, indicating their epidermoid origin. Tumor growth after...

... mapping of these overrepresentations by interphase fluorescence in situ hybridization (FISH) of tumor cells in cell lines. Methods: Seven cell lines derived from squamous cell carcinomas of the head and neck were investigated by comparative genomic hybridization to analyze unbalanced chromosomal...

... alterations in 32 primary PCs including 4 cases with distant organ metastasis using comparative genomic hybridization coupled with tissue microdissection and degenerate oligonucleotide primed polymerase chain reaction (DOP-PCR). The present study revealed frequent gains of chromosomes 13q and 15q and a loss...

... alterations between tumors of these organs, we applied comparative genomic hybridization (CGH) to cancers of the liver (31 cases), biliary tract (42 cases) and pancreas (27 cases). Some alterations were common to tumors of all three organs, and some were preferential in certain types of tumor. Gains of 1q...

... detected by comparative genomic hybridization (CGH) in 12 ovarian clear cell adenocarcinomas. DNA sequence copy number abnormalities (CNAs) occurring in more than 20% of the cancers included increased copy numbers of 8q11-q13, 8q21-q22, 8q23, 8q24-qter, 17q25-qter, 20q13-qter and 21q22-qter and reduced...

...Kei Shiraishi; Noriyoshi Kusano; Satoshi Okita; Atsunori Oga; Kiwamu Okita; Kohsuke Sasaki In order to elucidate cytogenetic changes characteristic of biliary tract cancer, we examined the genetic imbalances in 18 biliary tract cancers using comparative genomic hybridization (CGH). The most common...