...Kyoung Min Kim; Woo Sung Moon; Gi Won Ha; Ho Sung Park; Kyu Yun Jang; Min Ro Lee; Myoung Ja Chung; Ae Ri Ahn Introduction: In colorectal cancer (CRC), the prognostic significance of Adenomatous polyposis coli ( APC ) mutations remains controversial. We aimed to investigate the effect of APC...

...Yu Liang; Yongmin Li; Rui Guo; Yan Zhao; Huanshuo Miao; Hong Chang; Yue Chen Introduction: Neuroendocrine differentiation is often found in colorectal cancer, but its impact on prognosis remains controversial. This study explored the association between neuroendocrine differentiation and prognosis...

... and appears to be involved in the pathogenesis of cancer. Our purpose was to assess the association of mRNA expression and genetic polymorphism of BACE2 in colorectal cancer (CRC) susceptibility and its association to clinicopathological factors in Swedish patients with CRC. Methods: A total of 720 CRC...

..., further research is needed to explore the influence of USP52 on the prognosis of colorectal cancer (CRC), the tumor immune microenvironment, and therapeutic response. Methods: The differential expression of USP52 between CRC and normal tissues was analyzed using multiple public databases. The relationship...

...Ali Alkan; Gümran İlay Doğaner; Özgür Tanrıverdi Introduction: This study aimed to show the relationship between the serum uric acid level measured at diagnosis and the BRAF mutation status in the primary tumor tissue in patients with metastatic colorectal cancer. Methods: In this retrospective...

...Koji Numata; Manabu Shiozawa; Yukari Ono; Kenta Iguchi; Mamoru Uchiyama; Masahiro Asari; Yasushi Rino; Aya Saito Introduction: Anti-p53 antibody (p53Ab) is useful for monitoring colorectal cancer (CRC) recurrence. We retrospectively analyzed the clinical impact of p53Ab ratio (p53R) before...

..., instructions or products referred to in the content or advertisements. 2024 Pseudomyxoma peritonei Colorectal cancer DNA methylation GNAS mutation KRAS mutation Pseudomyxoma peritonei (PMP) is a rare disease caused by neoplasms disseminated in the abdominal peritoneum with an estimated...

... mismatch repair proficient (pMMR) colorectal cancer (CRC). This study aimed to investigate the role of Xerna™ TME Panel in predicting the treatment response. Methods: Twenty-two archival pretreatment tumor samples were subjected to the Xerna™ TME Panel, a machine learning-based RNA-sequencing biomarker...

...Chenglou Zhu; Dandan Ji; Jichun Ma; Mingxu Da In this study, clinical trials were generalized, summarized, and meta-analyzed to evaluate correlations between artificial sweeteners (ASs) and colorectal cancer (CRC). PubMed, Web of Science, Embase (Ovid platform), MEDLINE, and the Cochrane Library...

...Yusuke Miyagawa; Masato Kitazawa; Shigeo Tokumaru; Satoshi Nakamura; Makoto Koyama; Yuta Yamamoto; Satoru Miyazaki; Nao Hondo; Yuji Soejima Introduction: Ovarian metastasis of colorectal cancer is known to have a poor prognosis. This study aimed to elucidate the characteristics of patients who...

...Nefeli Giannopoulou; Constantina Constantinou Background: Colorectal cancer was reported as the second most common cause of cancer death worldwide, in the year 2020. This disease is an important public health problem considering its high incidence and mortality rates. Summary: The molecular events...

...Tae-Woo Kim; Soon Woo Hwang; Kyeong Ok Kim; Jae Myung Cha; Young-Eun Joo; Young-Seok Cho Introduction: KRAS , BRAF , and DNA mismatch repair (MMR) mutations aid clinical decision-making for colorectal cancer (CRC) patients. To ensure accurate predictions, the prognostic utilities...

...Kazuaki Okamoto; Hiroaki Nozawa; Shigenobu Emoto; Koji Murono; Kazuhito Sasaki; Soichiro Ishihara Introduction: Adjuvant chemotherapy improves the prognosis of patients with colorectal cancer (CRC) following radical resection. However, the safety and efficacy of oxaliplatin-based chemotherapeutic...

...Kajsa Björkman; Tuomas Kaprio; Ines Beilmann-Lehtonen; Ulf-Håkan Stenman; Camilla Böckelman; Caj Haglund Objectives: Colorectal cancer is the third most common cancer worldwide, with an obvious need for more accurate prognostics. Previous studies identified C-reactive protein (CRP) as a prognostic...

..., MMP-9, and MPO, as well as carcinoembryonic antigen (CEA), CA19-9, and C-reactive protein (CRP) in colorectal cancer with operable liver metastases. Methods: This study included 419 patients who underwent liver resection for colorectal metastases at the Helsinki University Hospital between 2000...

...Ines Beilmann-Lehtonen; Jaana Hagström; Tuomas Kaprio; Ulf-Håkan Stenman; Karin Strigård; Richard Palmqvist; Ulf Gunnarsson; Camilla Böckelman; Caj Haglund Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy globally. CRC patients with elevated plasma C-reactive...

...Ines Beilmann-Lehtonen; Jaana Hagström; Harri Mustonen; Selja Koskensalo; Caj Haglund; Camilla Böckelman Background: Colorectal cancer (CRC), the third most common cancer globally, caused 881,000 cancer deaths in 2018. Toll-like receptors (TLRs), the primary sensors of pathogen-associated molecular...

...Athanasios Tampakis; Ekaterini Christina Tampaki; Afroditi Nonni; Michael Kontos; Gerasimos Tsourouflis; Alberto Posabella; Lana Fourie; Martin Bolli; Gregory Kouraklis; Markus von Flüe; Evangelos Felekouras; Nikolaos Nikiteas Background: Disease recurrence in colorectal cancer constitutes a major...

...Gianluigi De Renzi; Giulio Gaballo; Paola Gazzaniga; Chiara Nicolazzo According to the 2018 GLOBOCAN database, colorectal cancer is one of the most common malignancies and leading causes of cancer-related death worldwide. During the last decades, considerable progress has been made in understanding...

...Reetta Peltonen; Jaana Hagström; Taina Tervahartiala; Timo Sorsa; Caj Haglund; Helena Isoniemi Introduction: The liver metastases of colorectal cancer (CRC) can be surgically treated in selected cases, with continuously improving results. Matrix metalloproteinases (MMPs) contribute to cancer...