... neoadjuvant chemotherapy (NACT). We hereby conducted a meta-analysis examining 5-year overall survival (OS) and disease-free survival (DFS) of such patients. Methods: PubMed, the Cochrane CENTRAL Library, Embase, Web of Science, and Scopus were searched up to July 30, 2024, for studies reporting survival data...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 Pancreatic cancer Nal-IRI S-1 Chemotherapy Pancreatic cancer (PC...

... patients requiring no additional therapy and others receiving chemotherapy. Pregnancy outcomes were generally favorable, with most neonates born healthy at term. However, one case of Richter transformation resulted in maternal death despite treatment. Among patients with pre-existing CLL ( n = 9...

[email protected] 16 05 2023 3 08 2023 4 12 2023 Even with the increasing occurrence of biliary tract cancer (BTC) [ 1 ], treatment strategies are very limited [ 2 ]. Surgery is the only radical treatment and the only evidence-based systemic chemotherapy is the combination...

... ( p < 0.01) or ICIs ( p = 0.03) compared with cytotoxic agents. Percent-predicted vital capacity ( p = 0.03) and epidermal growth factor receptor gene mutation ( p < 0.01) were significant factors affecting the overall response to chemotherapy in multivariate analysis. Conclusion: EGFR-TKIs...

... (LARC), initial treatment with neoadjuvant chemoradiotherapy followed by surgery and chemotherapy in selected patients is considered one of the recommended options by the main international clinical guidelines. Nonetheless, the administration of all chemotherapy before definitive treatment (total...

...Anne M.S. de Hoop; Karin Valkenet; Jaap J. Dronkers; Cyrille A.M. Krul; Jelle P. Ruurda; Cindy Veenhof; Raymond H.H. Pieters Introduction: Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise has been shown to positively influence...

..., instructions or products referred to in the content or advertisements. 2023 Chemotherapy Metastatic colorectal cancer Prognosis Early-onset metastatic colorectal cancer Advancements in local and systemic therapies, coupled with the implementation of screening colonoscopies, have contributed...

... concentrations. Few studies have assessed the correlation between the GPS and the efficacy of chemotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC). Therefore, this study aimed to evaluate the utility of the GPS in predicting the survival outcomes of patients with ES-SCLC. Methods...

...Naoki Fukuda; Ryosuke Oki; Hirotaka Suto; Xiaofei Wang; Tetsuya Urasaki; Yasuyoshi Sato; Kenji Nakano; Mayu Yunokawa; Makiko Ono; Junichi Tomomatsu; Hiroki Mitani; Shunji Takahashi Introduction: Although systemic therapy, including multi-kinase inhibitors and cytotoxic chemotherapy, is an option...

... Yasuda Introduction: Third-line chemotherapy has been suggested to improve survival in patients with gastric cancer. This study aimed to identify factors associated with the induction of third-line chemotherapy for advanced gastric cancer, focusing on patient eligibility for clinical trial. Methods: We...

... significance of eligibility criteria determined by phase 3 clinical trials in the clinical practice of patients with advanced gastric cancer who underwent chemotherapy. Methods: Patients with stage IV gastric cancer who received chemotherapy between February 2002 and December 2021 were retrospectively enrolled...

...; Hiroshi Miyata Background: Preoperative chemoradiation therapy (CRT) or chemotherapy (CT) followed by surgery is currently being administered for advanced esophageal cancer. However, few studies have directly compared CRT and CT for treating locally advanced esophageal carcinoma. This study aimed...

... Nakajima; Kazuhisa Takahashi Introduction: Cisplatin-based chemotherapy was established in the 1980s, and it has been improved by the development of a short hydration protocol in lung cancer therapy. However, cisplatin-based chemotherapy is still associated with renal toxicity. Because 5-aminolevulinic...

...Hee Jun Choi; Jun Ho Lee; Chang Shin Jung; Jeong Eon Lee; Youn Joo Jung; Seungju Lee; Seok-Kyung Kang; Hyun Yul Kim Introduction: Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) is associated with improvement in survival outcomes. This study evaluated the pCR in patients...

... Introduction: Synovial sarcoma (SS) predominantly affects adolescents and young adults. Doxorubicin with or without ifosfamide therapy is the standard first-line treatment for unresectable or metastatic SS. However, there is no standard second-line chemotherapy regimen. The purpose of the current study...

...Hyera Kim; Ehyun Choi; Mi Hwa Heo; Jin Young Kim; Keon Uk Park Background: Elderly patients with extensive-disease small-cell lung cancer (ED-SCLC) have a high risk of chemotherapy toxicity due to multiple comorbidities and poor performance status. Although dose modification is often used to avoid...

... Background: The clinical benefit of systemic chemotherapy for recurrent/metastatic retroperitoneal/intra-abdominal soft tissue sarcoma (STS) compared to its benefits for other primary lesions has not been known or sufficiently evaluated. Methods and Patients: We retrospectively reviewed the cases of the STS...

... 1 (LAT-1) in clinical gastric cancer (GC) patients could predict patient therapeutic response to postoperative adjuvant chemotherapy. Methods: Immunohistochemistry was used to investigate LAT-1, CD98, and phosphorylated-mammalian target of rapamycin (p-mTOR) expression in 111 GC patients. To clarify...

...–0.93, p = 0.0162), and in patients who have started taking metformin after chemotherapy versus before chemotherapy and never users (HR 0.44, 95% CI 0.26–0.73, p = 0.0016). Conclusions: Our results highlighted that vitamin D intake improves DFS in patients undergoing surgery. Metformin intake after...