.... Anthracyclines Breast cancer Chemosensitivity Primary neoadjuvant chemotherapy Topoisomerase II alpha The delivery of chemotherapy preoperatively in the neoadjuvant setting is an option in all cases that would require adjuvant chemotherapy after surgery [ 1 ]. The response to neoadjuvant chemotherapy...

...R. Abe; H. Ueo; T. Akiyoshi The MTT assay in agarose, a simple colorimetric test performed in double-layer agarose, has been evaluated for chemosensitivity testing of fresh tumor samples from human cancers in comparison with the MTT assay. The absorbance of cells from fibroblast cell lines...

...Tsuyoshi Akiyoshi; Tetsuya Wada; Yasuya Nakamura Utilizing a simplified tritiated thymidine incorporation assay, in vitro chemosensitivity of tumor cells obtained from malignant effusions was assessed and, in these patients, chemotherapeutic drugs were administered directly into the peritoneal...

...Takashi Kanematsu; Yoshihiko Maehara; Takashi Matsumata; Ken Shirabe; Kouhei Akazawa; Keizo Sugimachi Chemosensitivity of hepatocellular carcinoma tissues from 72 patients to 6 antitumor agents was assayed using the succinate dehydrogenase inhibition test. Sensitivity was positive in 47.2...

..., although the difference was not significant. In vitro chemosensitivity was higher in the smaller nodes and this tendency corresponded well to the clonogenicity. The data showed that the clonogenicity and in vitro chemosensitivity were high in the early phase of locoregional lymph node metastasis...

...Hiroaki Ueo; Yoshihiko Maehara; Atsushi Saito; Yoshihisa Sakaguchi; Shunji Kohnoe; Keizo Sugimachi The chemosensitivities of 62 human colon cancer tissues, 67 rectal cancer tissues and 31 tumor-adjacent normal mucosal tissues were determined using the in vitro succinate dehydrogenase inhibition...

...Tetsuya Kusumoto; Yoshihisa Sakaguchi; Yoshihiko Maehara; Tadashi Nakashima; Motonosuke Furusawa; Keizo Sugimachi The chemosensitivities of squamous cell carcinoma (SCC) tissues from the head and neck area were compared to findings of adenocarcinoma, mainly from digestive organs. The sensitivity...

...Tadashi Nakashima; Takuya Uemura; Yoshihiko Maehara; Keizo Sugimachi In vitro chemosensitivity was evaluated in human head and neck cancers using the succinate dyhydrogenase (SD) test and the results were compared to findings in cases of malignant lymphomas and gastric cancers. Tumor fragments were...

.... Thermosensitivity Chemosensitivity Thermochemosensitivity Human tumor clonogenic assay Colorectal cancer Oncology 45: 236-241 (1988) < 19X8 S. K arger A G , Basel 0030 2414 88 0453 0236 $2.75 0 Thermochemosensitivity: Augmentation by Hyperthermia of Cytotoxicity of Anticancer Drugs against Human Colorectal...

...Hideaki Anai; Yoshihiko Maehara; Hiroki Kusumoto; Tetsuya Kusumoto; Keizo Sugimachi The chemosensitivity of 20 human neoplastic tissues including 13 gastric and 7 colorectal cancers was tested using 5-fluorouracil (5-FU) and its analogues: 1-(2-tetrahydrofuryl)-5-FU (FT), uracil/FT (UFT) and l...

...J.E. Byfield; J.J. Stein; L.R. Bennett The technical aspects and preliminary results of an in vitro radioassay for tumor chemosensitivity are described. A representative series of gynecologic cancers has been studied. The procedure monitors inhibition of uptake of protein and nucleic acid...

...Shinji Morita; Satoru Iida; Keiji Kato; Yoko Takagi; Hiroyuki Uetake; Kenichi Sugihara Purpose: We investigated whether a 5-fluorouracil (5-FU)-resistant tumor could regain chemosensitivity after the administration of 5-aza-2′-deoxycytidine (DAC) as a demethylating agent. Methods: Human colorectal...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Biochemical modulation Chemosensitivity...

... is involved in the chemotherapeutic response. Methods: Proliferation rate was measured by XTT cell viability assay in the presence or absence of chemotherapeutics. Chemosensitivity was also measured by colony formation assay. Expression of p53 was investigated by immunoblot analysis. The mutational hot spot...

... to gemcitabine in an in vitro chemosensitivity test. SKS cells were small round cells with a high nuclear/cytoplasmic (N/C) ratio and grew into colony-like aggregates, forming spherical aggregates of floating cells. The population doubling time was 44 h. The number of chromosomes ranged from 50 to 56...

... Treatment outcome Toxicity Chemosensitivity Review Oncology 1998;55:265 275 Richard Greil Division of Hematology and Oncology, Department of Internal Medicine, University of Innsbruck, Austria Prognosis and Management Strategies of Lymphatic Neoplasias in the Elderly II. Hodgkin s Disease...

... Intermediate-/high-grade malignancy Burkitt’s non-Hodgkin’s lymphoma Acute lymphocytic leukemia Elderly patients Prognostic factors Treatment outcome Toxicity Chemosensitivity Review Oncology 1998;55:189 217 Richard Greil Division of Hematology and Oncology, Department of Internal Medicine...