... by Western blot. Results: Cell proliferation and survival were increased by EGF and inhibited by AG1478. The EGFR inhibitor also altered the cell cycle, inducing arrest in G1 and increasing the sub-G1 population, reduced polyploidy and increased the population of senescent cells. In addition, AG1478 reduced...

... an incurable disease. Methods: To evaluate treatment strategies on MM cells, the effects of radiotherapy, docetaxel or a combination of both on MM cells derived from the sarcomatoid type ZL34 and the epithelial type M28K were investigated. The TP53 gene, micro-RNA expression, cell cycle distribution and cell...

... signaling on the expression of Shh signaling components and cell cycle-related regulators was determined by immunoblotting and quantitative RT-PCR, respectively. Results: The expression of Pacthed1, Gli1 and Gli2 was detected in 70, 70, and 65% of human ONB specimens, respectively, and in proportion of ONB...

... cytometry (FCM) to elucidate the relationship between the expression of p53 and the cell cycle in A431 cells. Fluorescence in situ hybridization proved that an A431 cell had two p53 genes whereas chromosome 17 was tetraploid. FCM showed that A431 cells expressed constantly high levels of p53 during the cell...

...Isao Sekiguchi; Mitsuaki Suzuki; Taw Tamada; Nariyoshi Shinomiya; Sumiaki Tsuru; Michisato Murata We evaluated the effects of cisplatin on the cell kinetics, cytomorphological changes, and cleavage patterns of DNA in two lines of human ovarian carcinoma cells. KF-1 cells displayed a cell cycle...

... of cultured target cell lines. In this report it is shown that the susceptibility to lysis of NK target cells depends on the growth phase of these cells but is independent of the cell cycle. These results may be important for interpreting NK cell data, may have some implications for transplantation...

..., instructions or products referred to in the content or advertisements. Mesna SCE Chromosome aberrations Cell cycle Oncology 40: 287-289 (1983) © 1983 S. Kargcr A G. Basel 0030-2414/83/0404.0287 $2.75/0 Cytogenetic Testing of Mutagenic and Radioprotective Effects of Mesna1 Reinhard Becher, Surabhi...

...L.B. Mekler The paper collates a series of data arrived at by different authors in the study of molecular and cellular phenomena which are observed in chemical carcinogenesis and during the formation and turnover of macromolecules of normal cell plasma membrane at different phases of the cell cycle...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chemical carcinogenesis Lymphocytes Cell cycle Cell division Cell membranes Viral carcinogenesis Conformational...

... for cell cloning and for adaptation to monodisperse suspension cultures are described. The cell cycle of AV3/INO cells was studied by pulse-labeling with tritiated thymidine. An interesting phenomenon, a very peculiar and probably significant intracell formation is described. Intracells are classified...

... in a significant inhibition in Plk1 expression in the cells. We found that the targeted depletion of Plk1 caused a dramatic mitotic catastrophe (mitotic cell cycle arrest as well as defects in several mitotic events such as incomplete separation of sister chromatids and failure of cytokinesis) followed by massive...

... cells were transfected with RNA interference plasmid targeted against PLK1 gene. Western blot was used to examine PLK1 expression in transfected cells. Proliferation, cell cycle and apoptosis were monitored by MTT and flow cytometry. Results: The expression rate of PLK1 in NHL was 63.6% (56/88). In B...

...-phase of the cell cycle and DNA ploidy with AgNOR count. Methods: Multiparametric DNA flow-cytometric analysis and AgNOR count were performed on cervical smear samples, cytologically diagnosed as normal (n = 196), atypical squamous cells of unknown significance (ASCUS, n = 98) and various grades...

... Compounds That Inhibit Histone Deacetylase, and Induces Growth Inhibition, Cell Cycle Arrest and Apoptosis in Human Endometrial and Ovarian Cancer Cells Noriyuki Takai Tami Ueda Masakazu Nishida Kaei Nasu Kaho Matsuda Mamiko Kusumoto Hisashi Narahara Department of Obstetrics and Gynecology, Faculty...

...). The loss of p27 Kip1 protein is suggested to be due to the enhancement of its posttranslational degradation. In the present study, to evaluate the effects of p27 Kip1 transfection on the cell cycle, we transfected OSCC cell lines with a high activity of p27 Kip1 degradation with p27 Kip1 threonine 187...

... of the cell cycle. pRb expression did not correlate with any clinicopathological features. Cyclin D1 overexpression was more frequently observed in cases with poor or moderate differentiation and with lymph node metastasis. Cyclin D1 overexpression and aberrant p53 expression showed direct relationships...