...Izzet Dogan; Inci Kizildag; Selnur Özkurt; Kamuran Ibis; Sezai Vatansever; Pinar Saip; Adnan Aydiner Introduction: Patients with HER2-positive metastatic breast cancer are at risk for developing brain metastases. Different anti-HER2 treatments can be used in the management of the disease...

... with brain metastases (BM). Although BM have historically been associated with poor prognosis, it is unclear whether they remain a strong predictor of reduced survival. This study aimed to evaluate the prognostic value of BM and the utility of the Lung-molGPA. Methods: This single-center retrospective...

...Hironori Yoshida; Young Hak Kim; Shigeaki Iwatsubo; Chikara Sakaguchi; Yuichi Sakamori; Hiroki Nagai; Hiroaki Ozasa; Tadashi Mio; Toyohiro Hirai Background: Brain metastases (BM) are one of the strongest negative prognostic factors in patients with non-small cell lung cancer (NSCLC). Molecularly...

...Giorgio Frega; Ingrid Garajová; Andrea Palloni; Maria Aurelia Barbera; Marco Trossello Pastore; Luca Faccioli; Luca Spinardi; Stefania De Lorenzo; Marta Cubelli; Maria Abbondanza Pantaleo; Guido Biasco; Giovanni Brandi Objective: Brain metastases (BMs) from biliary tract cancer (BTC) are extremely...

...Rimas V. Lukas; Patrik Gabikian; Madeline Garza; Steven J. Chmura Brain metastases are associated with substantial morbidity and mortality. Key prognostic classification systems for brain metastases are reviewed. The role of surgery, particularly for single brain metastases, is discussed...

... whether patients undergoing trimodality therapy (TMT) should be screened or surveyed for brain metastases. Methods: We retrospectively analyzed esophageal cancer (EC) patients who underwent TMT between the years 2000 and 2010. All were systematically staged and surveyed but none had screening...

...H.J. Boyle; E. Jouanneau; J.P. Droz; A. Fléchon Background: Brain metastases from germ cell tumors (GCT) are rare and treatment has not yet been standardized. Methods: The clinical data of men with brain metastases from GCT treated in a single cancer hospital from January 1993 to September 2007...

... to in the content or advertisements. Trastuzumab HER2 Lapatinib Metastatic breast cancer Clinical practice Brain metastases Chemotherapy The main objective of the study was to describe therapeutic strategies in Swiss clinical practice in patients with HER2-positive MBC. Physicians from six Swiss...

...Carsten Nieder; Jan Norum; Jørn G. Stemland; Astrid Dalhaug Objective: In spite of the large number of patients and increasing financial pressure on health care budgets worldwide, limited data on resource utilization after diagnosis of brain metastases are available. Methods: Prospective data were...

... (range 6–52) and in NSCLC 29.8 weeks (range 2–99). The combination of carboplatin and etoposide is highly successful in the treatment of cerebral metastases from lung cancer and it could be a valid alternative to the traditional radiotherapy. Brain metastases Lung cancer Chemotherapy © 1996 S...

... lesions. We reviewed patients treated at Massachusetts General Hospital for posterior fossa brain metastases from various primary cancers, and evaluated the risk of concomitant or subsequent ISM. Of 104 patients, 10 developed ISM, with a 1-year actuarial risk of 25%. The risk was not significantly related...

... metastases from colorectal cancer treated between 1983 and June 2008 in Northern Norway. The patients were assigned to 3 different groups, based on the decade of treatment. Results: The time interval between first cancer diagnosis and brain metastases has significantly increased over time. The use...

...). The demonstrated efficacy of prophylactic cranial irradiation (PCI) in small-cell lung carcinoma led to studies of its effectiveness in LA-NSCLC, which indicated that PCI also has a high potential to reduce the incidence or delay the occurrence of brain metastases in this patient group. This report provides...

...John V. Brown III; Howard D. Epstein; Richard Kim; John P. Micha; Mark A. Rettenmaier; Julie A. Mattison; Bram H. Goldstein Objectives: Brain metastases originating from primary cervical carcinoma are very rare. Despite surgery and adjuvant therapy, patient prognosis is extremely unfavorable. Prior...

...Carsten Nieder; Reinhard Thamm; Sabrina T. Astner; Hans Geinitz; Michael Molls Objective: The outcome of whole-brain radiotherapy in elderly patients with brain metastases is not well documented. As the number of such patients is expected to increase, we evaluated our results. Methods: Seventeen...

...Annette N.Y. Poon; Simon S.M. Ho; Winnie Yeo; Tony S.K. Mok A woman with stage IIIb non-small cell lung cancer (NSCLC) developed disease progression with brain metastases during chemotherapy. Due to unusual circumstances, the patient received gefitinib alone, without the use of corticosteroid...

... to be a standard therapy for metastatic non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the activity and toxicity of this combination with vinorelbine or gemcitabine as front-line therapy in brain metastases from NSCLC. Methods: Twenty-six chemotherapy-naive patients with an ECOG...

...Akihisa Fujita; Seiji Fukuoka; Hirotsugu Takabatake; Shigeru Tagaki; Kyuhichiro Sekine Background: Brain metastases develop frequently in patients with non-small cell lung cancer (NSCLC), and the prognosis for these patients is very poor. We evaluated the role of chemotherapy for patients...