...Jie Chen; Suna Fu; Jianhong Yu; Qi Tang; Xiuping Wu; Sai Luo; Huifang Sun Introduction: The aim of this study was to investigate the association of pre-treatment-modified Glasgow Prognostic Score (mGPS) with survival-related outcomes in patients with bladder cancer (BC) and prostate cancer (PC...

... in bladder cancer (BLCA). The validation cohort for immunotherapy corroborated these findings and substantiated that ESCO2 could function as an autonomous prognostic biomarker and a promising target for cancer treatment via immunotherapy. In addition, in vitro experiments confirmed the role of ESCO2...

... Introduction: Bladder cancer (BC) is sensitive to radiation treatment and a subset of patients experience radiation-induced injuries including shrinkage of bladder due to bladder fibrosis. Methods: This study is a retrospective cohort study. Three Japanese BC patients were randomly selected. Using a microRNA...

..., instructions or products referred to in the content or advertisements. Metallothionein 2A MT2A Upper tract urothelial carcinoma Bladder cancer Prognosis Urothelial carcinoma (UC), which occurs in the mucosa of the urinary tract, is an important neoplasm of the urinary system that is usually...

...Hong Ku Ha; Phillip J. Koo; Seong-Jang Kim Aims: We aimed to assess the diagnostic accuracy of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for preoperative lymph node (LN) staging in newly diagnosed bladder cancer (BC) patients through a systematic review...

... evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). Methods: The analysis enrolled 117 patients and the variables included age...

... of care for muscle-invasive urothelial bladder cancer. Gemcitabine plus cisplatin (GC) shows similar efficacy with less toxicity in the metastatic setting and has therefore often been used interchangeably with MVAC. We report on the efficacy and safety of neoadjuvant GC in patients with locally advanced...

.../metastatic bladder cancer. This phase I study examined the safety of lapatinib in combination with GC in patients with bladder cancer. The primary aim was to determine the maximum tolerated dose (MTD) of lapatinib in combination with GC. Methods: A 3 + 3 dose escalation protocol was used with lapatinib...

... on bladder cancer remains obscure. In the present investigation, we examined the expression of TRPM8 and the role of menthol in cells of the human bladder cancer cell line T24. Methods: RT-PCR, Western blotting and immunocytochemistry were used to confirm the expression and location of TRPM8 in T24 cells...

...) and epirubicin regimens in patients with superficial bladder cancer. One hundred thirty-two individuals with recurrent and/or multiple neoplasms, i.e. at high risk for tumour recurrence and progression, were enrolled. After complete transurethral resection of their tumours, the patients received a 6-week course...

...N. Mottet-Auselo; F. Bons-Rosset; P. Costa; J.F. Louis; H. Navratil The prognosis of advanced-stage bladder cancer is poor. Chemotherapy, particularly regimens including platinum salts, appears to increase survival moderately but at the cost of severe, mainly renal toxicity. Platinum is a major...

...-treated group (p < 0.001). Lung metastasis was observed in all treatment and control groups. This model has specific reproducible characteristics which make it a useful murine tumor model to study locally invasive bladder cancer. 11 6 2009 © 1984 S. Karger AG, Basel 1984 Copyright / Drug...

.... The incidence of positives among normal donor’s and early stage bladder cancer patients was much lower, viz. 3.6 and 6.7%, respectively. The same sera were also tested for their staining reactions against surface antigens of bladder tumour cells. Again sera from a higher proportion of chemical workers (28.6...

..., a comparative genomic hybridization technique was applied for 8 established bladder cancer cell lines, and these results were compared with the in vitro fluorescent expression experiment. Results: Fluorescent mucosa was detected in 33 of the 34 malignant tissue specimens (16 carcinoma in situ, 18 other...

...Sonata Jarmalaite; Feliksas Jankevicius; Kristina Kurgonaite; Kestutis Suziedelis; Pertti Mutanen; Kirsti Husgafvel-Pursiainen Aims: Superficial bladder cancer is a highly recurrent disease, with progression to muscle invasiveness occurring in 15–30% of cases. Promoter hypermethylation in a panel...

...Yoshiaki Yamamoto; Yasuyo Chochi; Hideyasu Matsuyama; Satoshi Eguchi; Shigeto Kawauchi; Tomoko Furuya; Atsunori Oga; Jason J. Kang; Katsusuke Naito; Kohsuke Sasaki Objective: To search for a biological marker to distinguish low-risk from high-risk bladder cancer indicating disease progression...

..., there are few reliable markers to distinguish these tumors with aggressive characteristics from tumors with a low malignant potential. Recent studies have reported overexpression of polo-like kinase 1 (PLK1) in several human cancers [ 2, 3 ] including bladder cancer [ 4 ]. PLK1 overexpression has been...

...Marcilei E. Buim; Fernando A. Soares; Álvaro S. Sarkis; Maria Aparecida Nagai Objective: The aim of the present study was to identify differentially expressed genes that might be associated with the phenotype of superficial and invasive bladder cancer. Methods: Differential display reverse...

... bladder cancer cells following irradiation. Methods: KK47 cells were irradiated with various doses of radiation and were examined for CH immunostaining for γ-tubulin. Results: Nearly all control cells contained one or two centrosomes, and mitotic cells displayed typical bipolar spindles. The centrosome...

...J. Carles; M. Nogué; M. Domènech; C. Pérez; E. Saigí; K. Villadiego; I. Guasch; R. Ibeas Introduction: Bladder cancer is a frequently occurring tumour in Spain and usually affects elderly patients with renal impairment. The development of new combination therapies for such patients is thus of vital...