... to represent a specific signature in tumor and/or adjacent healthy tissues, based on tumor location and patients’ age. Analyzing differential HERV expression and its correlation with clinicopathological patient characteristics could be valuable for identifying novel biomarkers and exploring potential...

... Biomarkers Immunology Cancer Chemotherapy Yearly, millions of people are diagnosed with cancer worldwide; in 2020, over 18 million new cases were reported [ 1 ]. Both the disease and common treatments such as chemotherapy and radiotherapy can have significant negative impact on daily functioning...

... upregulation of cytokines such as IL-6 has been implicated in cervical cancer development and progression through several mechanisms, for example, by inducing platelet production, activation, and aggregation. The aim of the study was to evaluate the effective prognostic impact of inflammatory biomarkers...

... the complex pathogenetic mechanisms involved in this neoplastic disease. Due to the need to improve treatment responses and clinical outcomes of colorectal cancer patients, the identification of new molecular biomarkers became a crucial spot in clinical oncology. As biological indicators of a specific...

.... Objectives: The aim of this study was to analyze the possible separated effects of smoking or HNSCC on 18 inflammatory or immune regulatory biomarkers. Methods: Fifty-one nonsmoking and 36 smoking pretreated HNSCC patients and 101 nonsmoking and 39 smoking controls were included in this study. The levels...

... analysis, miR-92a and miR-144* were significantly associated with the presence of CRC ( p = 0.03 and 0.011, respectively). Conclusions: The stool levels of miR-92a and miR-144* showed good sensitivity and fair specificity for detection of CRC, and thus may be useful as noninvasive biomarkers...

... ]. According to multivariate analysis, biomarker Ki67 ≥50% was the only independent predictor of cCR in breast (OR 2.00, 95% CI 1.31–3.06) and breast and axilla (OR 1.67, 95% CI 1.10–1.45), but none was identified in axilla. HER2-positive and molecular subtype were the independent predictors of pCR in women...

... FOLFIRINOX or gemcitabine. Six months of chemotherapy was recommended for patients who had a response. Metastatic pancreatic cancer FOLFIRINOX CA19-9 Biomarkers Pancreatic cancer is the fourth leading cause of cancer death in Europe and in the United States [ 1,2 ]. Prognosis remains poor...

...Eugenia Allegra; Serena Trapasso; Davide Pisani; Lidia Puzzo Emerging studies show that BMI1 (B cell-specific Moloney murine leukemia virus integration site 1) has an important function as a biomarker of cancer stem cells (CSCs), i.e. cells with self-renewal characteristics, capable of tumor...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Biomarkers Carcinogenesis Colorectal carcinoma Extracellular matrix Fibronectin Integrin Osteonectin Osteopontin Colorectal cancer (CRC) is the third most common malignant...

... characteristics and plasma biomarkers expression levels were analyzed. Results: PFS at 16 weeks was 64% (95% CI 51–76): 14 patients achieved partial response (24%), 33 had stable disease (56%), 6 progressed (10%), and 6 were not evaluable (10%). Median overall survival was 13.7 months (95% CI 9.6–19.7...

..., instructions or products referred to in the content or advertisements. Biomarkers Chemokine receptors CCR7 expression Hematogenous metastases Lymph node metastases Pancreatic ductal cancer Lymph node (LN) metastasis has been indicated as a major prognostic factor in resectable pancreatic...

... attempted to screen serum biomarkers to distinguish pancreatic cancer from non-cancer individuals. Methods: 47 serum samples from pancreatic cancer patients, 39 of whom had small surgically resectable cancers, were collected before surgery, and an additional 53 serum samples from age- and sex-matched...