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Keywords: Angiogenesis
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Journal: Oncology
Oncology (2016) 91 (4): 179–184.
Published Online: 03 August 2016
... of metformin's vascular actions can be seen in nondiabetic conditions. Metformin has an interesting potential to treat vascular dysfunction and tumor angiogenesis in conditions beyond diabetes. Since metformin's use in cancer as a single antiangiogenic agent appears to be a therapeutic disappointment, the use...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2013) 85 (2): 69–77.
Published Online: 16 July 2013
...Sabrina Mathey; Monika Karla Graeser; Christine zu Eulenburg; Linn Woelber; Fabian Trillsch; Fritz Jaenicke; Volkmar Müller; Karin Milde-Langosch; Sven Mahner Objectives: Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2012) 83 (2): 108–116.
Published Online: 09 July 2012
... of cetuximab in combination with platinum and fluorouracil, the median overall survival rate remains lower than 11 months. There are many possible reasons for these disappointing results including acquired drug resistance and tumor hypoxia. Angiogenesis plays an important role in HNSCC development...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2011) 81 (3-4): 259–272.
Published Online: 23 November 2011
...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Molecular pathways Pancreatic cancer, tumors Methylation Angiogenesis Based on rates from 2004–2006...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2011) 81 (2): 126–134.
Published Online: 06 October 2011
... expressed within the microvasculature of various malignancies. Moreover, transforming growth factor β (TGF-β), a negative prognostic factor for glioma, is intimately involved in angiogenesis including VEGFR2 regulation. Our objective was to associate expression of VEGFR2 and TGF-β activity...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2011) 79 (3-4): 187–196.
Published Online: 28 February 2011
.... Angiogenesis Advanced colorectal cancer Dendritic cells Immunophenotype Angiogenesis is a crucial step in the development of solid tumours, and several anticancer therapies have been optimized in order to block this phenomenon [ 1,2 ]. Bevacizumab, a monoclonal antibody neutralizing vascular...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2010) 77 (6): 385–394.
Published Online: 02 February 2010
... targeting VEGF significantly silenced VEGF expression in SKOV3 ovarian cancer cells, confirmed by RT-PCR and ELISA assays (p < 0.05). In vivo, the shRNA reduced tumor weight by ∼60.3% compared with control groups (p < 0.05), accompanied with angiogenesis inhibition (p < 0.01) and apoptosis...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1995) 52 (3): 226–229.
Published Online: 30 June 2009
...Lilia E. Davel; Maria A. Jasnis It is known that tumor cells activate spleen cells to induce an angiogenic response. In this report we studied whether different antigenic stimuli, other than tumor cells, were able to activate spleen lymphocytes to induce angiogenesis in syngeneic combination (SLIA...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1995) 52 (1): 51–54.
Published Online: 30 June 2009
... without metastasis was 19.4 ± 14.9 and 19.6 ± 17.4, respectively. Angiogenesis is apparently not a key factor in the formation of metastasis by MFH. 30 6 2009 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1997) 54 (3): 177–184.
Published Online: 30 June 2009
...Gunther Gastl; Thomas Hermann; Michael Steurer; Jörg Zmija; Eberhard Gunsilius; Clemens Unger; Andrea Kraft Angiogenesis is a key step in tumor growth, invasion and metastasis. Thus, antiangiogenic therapy was postulated to be an attractive approach for antitumor treatment. Based on today’s...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1997) 54 (4): 324–328.
Published Online: 30 June 2009
...Rafael E. Alcalde; Nagaaki Terakado; Kaname Otsuki; Tomohiro Matsumura It has been demonstrated that angiogenesis is required in the process of tumor progression and metastasis. Microvessel density (MVD) estimates tumor angiogenesis and is an independent indicator for predicting tumor metastasis...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2009) 77 (1): 1–11.
Published Online: 12 May 2009
...Andreas A. Argyriou; Efstathia Giannopoulou; Haralabos P. Kalofonos Angiogenesis is considered to be a regulating factor of vascular development and growth for malignant gliomas, including glioblastoma multiforme (GBM) and anaplastic astrocytomas. The mechanism of angiogenesis is primarily mediated...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2008) 75 (3-4): 127–133.
Published Online: 15 September 2008
... feature of metastasis. Another important fact to note is that MIF is capable of inducing angiogenesis. Investigators demonstrated that MIF enhances the differentiation of endothelial cells to blood vessels [ 54, 55 ]. Using MIF antibodies or antisense mRNA, it has been possible to detect significant...