...Toshiharu Sakurai; Masatoshi Kudo; Katsuhiko Itoh; U. Ryu; Hiroaki Higashitsuji; Jun Fujita Background: Melanoma antigen (MAGE)-A4 is processed to generate a C-terminal fragment with proapoptotic activity. Here we demonstrate that Adriamycin promotes generation of the processed MAGE-A4...

...-transfectant cells contained markedly elevated levels of CYPR protein, while wild-type Chinese hamster ovary cells contained low levels. They showed 1.8- to 3.3-fold higher sensitivity to Adriamycin, 2.1- to 3.0-fold higher sensitivity to mitomycin C, and 2.9- to 4.3-fold higher sensitivity to paraquat than...

... infusion of Adriamycin. 30 6 2009 © 1997 S. Karger AG, Basel 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including...

... I and II, Adriamycin (ADR) 4 mg/kg alone was given either into the hepatic artery or into the portal vein, respectively, 24 h after the inoculation of tumor cells. In groups III and IV, ADR mixed with lipiodol (lipiodolized ADR) 4 mg/kg was given into the hepatic artery or into the portal vein...

...George P. Stathopoulos; George S. Stergiou; Basil Golematis; Nikolaos Thalassinos; Michael Fillipakis One hundred and seventy-four patients with advanced colorectal cancer were treated with 5-fiuorouracil (5-FU), mitomycin-C (MIT-C) and Adriamycin (ADR) (FAM). The total response rate was 26.4...

... stages III and IV Chemotherapy Cyclophosphamide Doxorubicin Adriamycin Cisplatin Laparotomy, second-look Second-effort surgery Oncology 1991 ;48:7 12 « 1991 S. Karger AG. Basel 0030 2414 91 «4SI 0007 S 2.75 0 Chemotherapy (CAP) for the Treatment of Advanced Ovarian Cancer and Second-Effort...

...M.M. El-Mofty; V.V. Khudoley; S.A. Sakr; S.I. Osman; B.A. Toulon Injecting adult toads (Bufo regularis) subcutaneously in the dorsal lymph sac with adriamycin at a dose of 2 mg/kg body weight, once every 3 weeks for 20 weeks, induced hepatocellular carcinomas in 20 out of 100 animals. Metastases...

... included the following drugs in various combinations: cyclophosphamide, adriamycin, fluorouracil, carboplatin and etoposide (VP-16). Complete control of emesis was achieved in a third of the 39 patients. There was no statistically significant difference among the dose levels with regard to the patient’s...

...Clifton Stephens; Yeu-Ming Wang; Timothy E. Schultheiss; John H. Jardine Verapamil, a calcium channel blocker, reduces resistance of some tumors to Adriamycin by inhibiting Adriamycin efflux from resistant cells. This study shows that rabbits given 7 mg/kg of Adriamycin and 0.8 mg/kg of verapamil...

...Richard J. Lanham A case of metastatic ameloblastoma is presented which was resistant to treatment with adriamycin (doxorubicin), platinol (cis-platinum), Cytoxan (cyclophosphamide), dacarbazine (DTIC), and 5-fluorouracil (5-FU). The literature about treatment with chemotherapeutic agents...

...W.R. Bezwoda; A. Weaving; M. Kew; D.P. Derman Forty-seven patients with hepatocellular cancer were treated in a randomised trial comparing adriamycin + VM 26 + 5-Fluorouracil (5-FU) to mAMSA + VM 26 + 5-FU. Thirteen patients had a partial response to treatment (28%) and another 6 (13%) showed...

...Vathsala S. Basrur; Manik P. Chitnis; Ravi S. Menon Cell surface alteration was studied in a subline of murine lymphocytic leukaemia resistant to the broad-spectrum anticancer agent adriamycin (P388/ADR) employing concanavalin A(Con A)-induced agglutination and rearrangement of lectin receptors...

...Robert Burns Adriamycin (ADR; 10 mg/kg) was given to mice bearing a 5-day-old Ehrlich ascites carcinoma (EAC) at two different circadian times: 05.00 and 17.00 h. The incorporation of tritiated thymidine into DNA (DNA synthetic activity; DNA-SA) was studied in the epithelium of the tongue, ileum...

...Seema G. Pradhan; Vathsala S. Basrur; Manik P. Chitnis; Suresh H. Adwani The natural resistance of human chronic myeloid leukemia cells to adriamycin (ADR) was overcome by using the cell membrane modulator verapamil (VRP). The studies were done in vitro. [ 3 H] thymidine incorporation inhibition...

...P. Giannotti; F. Ambrogi; G.B. Ciottoli This paper reports the interim results of 25 patients included in a double-blind study in which the combination of Lonidamine plus adriamycin is compared to adriamycin alone in the adjuvant treatment of papillary carcinomas of the urinary bladder. Although...

...Shuichi Yoneda; Takeshi Honma; Seiichi Yoshida; Kyong Yob Min; Yukio Noguchi; Mizuyoshi Sakura 61 patients with inoperable non-small cell lung cancer were treated by combination chemotherapy with cisplatin, Adriamycin and cyclophosphamide. 23 patients received radiotherapy in addition...

...Cara-Lynne Schengrund; Beth Allyson Sheffler Cholinergic murine neuroblastoma cells, maintained in vitro, were exposed to a low concentration (0.4 μ g/ml) of adriamycin. Morphologically the treated cells appeared to differentiate. The cell bodies increased in size from an average fixed cell body...

... of the patients either before or after chemotherapy. Combination chemotherapy is effective in approximately 75% of the patients and offers the best palliation for the majority of the patients. Adriamycin-containing regimens have resulted in slightly superior results than combination regimens which exclude...

...D.V. Razis; E. Poulakou; A. Petounis; G. Papadimitriou; P. Kosmides; G. Delides During the last 2½ years, 38 patients with ovarian cancer were treated with a combination of cis-platinum (CPDD), 50 mg/m 2 , adriamycin, 30 mg/m 2 , cyclophosphamide, 300 mg/m 2 , on day 1; and hexamethylmelamine (HMM...

...Afaf M. Amin; Michael C. Lowe; Abdel Azim A. Ismail A study of the cardiotoxicity induced by adriamycin (ADR) was done on the heart tissue of Sprague-Dawley rats receiving a single intravenous dose (15 mg/kg). Condensed bright orange-red fluoresced chromatin was observed in the nuclei...