...) with unresectable liver metastases. Objective: The aim of this retrospective study was to assess HAIC of 5-fluorouracil (5FU) in patients with unresectable liver metastases from CRC refractory to standard systemic chemotherapy. Methods: A total of 137 patients (85 men, 52 women; median age, 62 years; with KRAS...

...Toshiyasu Ojima; Masaki Nakamura; Mikihito Nakamori; Masahiro Katsuda; Keiji Hayata; Shimpei Maruoka; Toshio Shimokawa; Hiroki Yamaue Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus...

...Giulia Pasquini; Enrico Vasile; Chiara Caparello; Caterina Vivaldi; Gianna Musettini; Monica Lencioni; Iacopo Petrini; Lorenzo Fornaro; Alfredo Falcone Purpose: The aim of this study was to evaluate the activity of the combination of 5-fluorouracil/folinic acid and irinotecan (FOLFIRI) as third...

...: Patients were genotyped for UGT1A1 and stratified according to the number of defective alleles (DA; *28 and *6). The irinotecan dose was escalated with a fixed dose of 5-fluorouracil and leucovorin in a standard 3 + 3 design. Results: In 43 enrolled patients, the maximum tolerated dose (MTD) was 300 mg/m 2...

..., Kim TW, Lee JL, et al: Bevacizumab plus FOLFIRI or FOLFOX as third-line or later treatment in patients with metastatic colorectal cancer after failure of 5-fluorouracil, irinotecan, and oxaliplatin: a retrospective analysis. Med Oncol 2009;26:32-37. 31. Geva R, Vecchione L, Tejpar S, et al...

... in patients with advanced gastric cancer. Methods: Eligible patients with chemotherapy-naïve advanced gastric cancer received low-dose everolimus (10 mg p.o. on days 1, 8 and 15) plus cisplatin and a weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin (HDFL) chemotherapy (cisplatin 35 mg/m 2...

...Kyu-Hyoung Lim; Sae-Won Han; Do-Youn Oh; Seock-Ah Im; Tae-You Kim; Yung-Jue Bang Objective: The purpose of this study was to determine the efficacy and safety of infusional 5-fluorouracil (5-FU), doxorubicin, and mitomycin-C (iFAM) as salvage chemotherapy in biliary tract cancer (BTC...

... the first day of treatment. Results: The area under the time-concentration curve (AUC) of 5-fluorouracil (5-FU) correlated with that of 5-chloro-2,4-dihydroxypyridine (CDHP, r = 0.750, p = 0.005). The AUC of CDHP correlated with the measured 24-hour creatinine clearance (CLcr) per subject ( r = –0.620, p...

... carcinoma 5-Fluorouracil Cisplatin Interferon Hepatocellular carcinoma (HCC) is the 6th most frequent type of cancer in the world and ranks third among the various causes of cancer death. In recent years, the incidence of HCC has been increasing in Western and Asian countries [ 1,2,3...

... or hyperalimentation. Performance status was 0–1 in 26 patients and ≧2 in the other 74 patients. Seventy-eight patients (78%) had peritoneal metastasis and 62 patients (62%) had ascites. First-line chemotherapy with 5-fluorouracil-based regimens was used in 46 patients, taxane-based chemotherapy in 34 patients, oral...

... therapy for HCC and it is not difficult to maintain; but the effective rate is not sufficient. Recently, the combination therapy of subcutaneous interferon (IFN)-α and intraarterial 5-fluorouracil (5-FU) showed an outstanding response rate for intractable HCC (with portal vein thrombosis). In addition...

...Kazuomi Ueshima; Masatoshi Kudo; Masahiro Takita; Tomoyuki Nagai; Chie Tatsumi; Taisuke Ueda; Satoshi Kitai; Emi Ishikawa; Norihisa Yada; Tatsuo Inoue; Satoru Hagiwara; Yasunori Minami; Hobyung Chung Background: Although hepatic arterial infusion chemotherapy (HAIC) using low-dose 5-fluorouracil (5...

... to in the content or advertisements. Paclitaxel Epirubicin 5-Fluorouracil Cyclophosphamide Breast cancer Neoadjuvant chemotherapy 30 11 2009 8 04 2010 2 7 2010 Table 2 Clinical response to therapy and surgical management Table 5 Adverse events The median...

...Edward Chu; Nianwen Shi; Wenhui Wei; Johanna C. Bendell; Thomas Cartwright Objective: To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. Methods: This retrospective...

...N. Pavlidis; C. Nicolaides; A. Athanassiadis; K. Beriatou; D. Skarlos; T. Giannakakis; P. Kosmidis; N. Karvounis; G. Fountzilas Preclinical data have shown a synergism between 5-fluorouracil and interferon-γ against human colon carcinoma cell lines. We conducted a phase II trial of this combination...

..., and 5-fluorouracil) chemotherapy were studied in premenopausal patients with node-positive breast cancer. Treatment consisted of standard CMF and locoregional radiotherapy (on indication). G-CSF was administered if the leukocyte count recovery was insufficient. Fifty-one patients required no G-CSF...

...Camillo Porta; Mauro Moroni; Giuseppe Nastasi; Giuseppina Arcangeli Twenty-five patients affected with unresectable hepatocellular carcinomas (HCCs) were treated with 370 mg/m 2 5-fluorouracil (5-FU) plus 200 mg/m 2 racemic leucovorin both for 5 consecutive days. The chemotherapy cycle was repeated...

...-hour intravenous (i.v.) infusion of methotrexate (MTX), 250 mg/m 2 , followed 24 h later by a 2-hour i.v. infusion of L -folinic acid (LFA), 250 mg/m 2 , and 5-fluorouracil (FU), 600 mg/m 2 as an i.v. bolus. Only 1 previously untreated patient obtained a partial response. The MTX serum level assessed...

... infusion of 5-fluorouracil (5-FU) 330 mg/m 2 /day plus low-dose cisplatin (CDDP) 6 mg/m 2 /day by bolus infusion on days 1–5. The regimen with a combination of 5-FU and low-dose CDDP (FLDP) was repeated weekly for two to four courses according to response and tolerance. In 24 (77%) of the 31 patients, four...

... Cajal, Madrid, s Hospital General, Badajoz, h Instituto Valenciano de Oncología, ' Hospital General Universitario, Valencia, Spain Key Words 5-Fluorouracil Tegafur UFT® Oral fluoropyrimidines Gastric cancer Non-small cell lung cancer Head and neck cancer Breast cancer Modulation Experience of Oncopaz...