In the article “Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy” [Oncology 2024;102(6):484–493. DOI: 10.1159/000535186] by Sugase et al., the values of the median follow-up period were used in place of the median progression-free survival period. The following corrections should be observed.
Abstract
The median period was incorrectly described as:
The median progression-free survival (PFS) and overall survival for ETS ≥20% and <20% were 12.7 and 5.5 months and 14.4 and 8.2 months and 12.7 and 4.9 months and 14.4 and 8.0 months for DpR ≥30% and <30%, respectively.
The correct description of the period is:
The median progression-free survival (PFS) and overall survival for ETS ≥20% and <20% were not reached (NR) and 5.5 months and NR and 9.5 months and NR and 4.9 months and NR and 8.3 months for DpR ≥30% and <30%, respectively.
Results
Early Tumour Shrinkage
The median period was incorrectly described as:
Patients with ETS <20% and ≥20% had median PFS of 12.7 months and 5.5 months, respectively (HR 0.11, 95% CI: 0.05–0.27, p < 0.001). All patients with ETS <20% had disease progression within 1 year of the date of diagnosis of metastatic or unresectable disease. Patients with ETS ≥20% and <20% had median OS durations of 14.4 months and 8.2 months, respectively (HR 0.10, 95% CI: 0.04–0.29, p < 0.001).
The correct description of the period is:
The median PFS of patients with ETS <20% and ≥20% was not reached (NR) and 5.5 months, respectively (HR 0.11, 95% CI: 0.05–0.27, p < 0.001). All patients with ETS <20% had disease progression within 1 year of the date of diagnosis of metastatic or unresectable disease. The median OS of patients with ETS ≥20% and <20 was NR and 9.5 months, respectively (HR 0.10, 95% CI: 0.04–0.29, p < 0.001).
Depth of Response
The median period was incorrectly described as:
Patients with a DpR of ≥30% and <30% had median PFS of 12.7 months and 4.9 months, respectively (HR 0.10, 95% CI: 0.04–0.23, p < 0.001). All patients with DpR <30% had disease progression within 1 year of the date of diagnosis of metastatic or unresectable disease. Patients with DpR ≥30% and <30% had median OS of 14.4 months and 8.0 months, respectively (HR 0.12, 95% CI: 0.05–0.32, p < 0.001).
The correct description of the period is:
The median PFS of patients with a DpR of ≥30% and <30% was NR and 4.9 months, respectively (HR 0.10, 95% CI: 0.04–0.23, p < 0.001). All patients with DpR <30% had disease progression within 1 year of the date of diagnosis of metastatic or unresectable disease. The median OS of patients with DpR ≥30% and <30% was NR and 8.2 months, respectively (HR 0.12, 95% CI: 0.05–0.32, p < 0.001).
Discussion
The median period was incorrectly described as:
In the present study, patients with ETS ≥20% showed a sufficient long-term response (median PFS 12.7 months) compared to the previous study with chemotherapy alone (median PFS 7.5 months).
The correct description of the period is:
In the present study, patients with ETS ≥20% showed a sufficient long-term response compared to the previous study with chemotherapy alone (median PFS 7.5 months).