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First page of Age-Stratified Risk of Carboplatin-Induced Nausea and Vomiting in Lung Cancer Patients

Introduction: Age has been reported as a risk factor for chemotherapy-induced nausea and vomiting. However, few reports have described risk factors for nausea and vomiting with carboplatin (CBDCA). This study investigated whether the incidence of CBDCA-induced nausea and vomiting differs with age, using 70 years as the cutoff. Methods: Patients who underwent CBDCA for lung cancer at the Cancer Institute Hospital of Japanese Foundation for Cancer Research between November 2020 and October 2023 were included in this retrospective study. The age cut-off was set at 70 years, with complete response (CR; no vomiting/retching and no rescue medication) rate during the observation period as the endpoint. Results: A total of 198 patients were included in the analysis, of whom 114 (57.6%) were ≥70 years old, with a CR rate of 36.9% for patients <70 years old and 61.4% for those ≥70 years old (p = 0.001). In univariate analysis, age <70 years old, female sex, no drinking history, no smoking history and CBDCA dose were associated with non-CR. In multivariate analysis, age <70 years old, no drinking history and CBDCA dose were associated with non-CR. Conclusion: Age <70 years old, no drinking history and CBDCA dose were identified as risk factors for CBDCA-induced nausea and vomiting.

Journal Section:
Clinical Study
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S. Karger AG, Basel
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2025
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