Background: Mobile health is a promising strategy aiming to anticipate and prevent the deterioration of health status in palliative cancer patients. A prerequisite for successful implementation of this technology into clinical routine is a high level of usability and acceptance of devices. Objectives: We aimed to evaluate feasibility as well as patients’ acceptance of remote monitoring using wearables in palliative cancer patients. Methods: In this prospective single-center observational feasibility study, 30 cancer patients treated with palliative intent in an inpatient setting with an estimated life expectancy of >8 weeks and <12 months were provided with a smartphone including a pre-installed “Activity Monitoring” app and a sensor-equipped bracelet and monitored over a period of 12 weeks starting at discharge from hospital. We report detailed feasibility and usability aspects and comment on patients’ acceptance of the wearables. Results: Between February 2017 and May 2018 a total of 30 patients were included in the study. From these, 25 participants (83%) completed the whole study period. On average, the bracelet was worn on 53% and smartphone used on 85% of the study days. The completion rate of daily digital questionnaires for subjective ratings (pain and distress scale) was 73%, and 28 patients were able to handle the wearables and to operate the app without major problems. Use of the bracelet was low during the night hours, with a wearing time of 1.7% of all night hours (8 p.m. to 8 a.m.). Conclusions: Remote monitoring of health care status in palliative cancer patients with a limited life expectancy is feasible and patients are able to handle the smartphone and the sensor-equipped bracelet. Feedback towards use of this monitoring system was mostly positive.

1.
Delgado-Guay
MO
,
Rodriguez-Nunez
A
,
Shin
SH
,
Chisholm
G
,
Williams
J
,
Frisbee-Hume
S
,
Bruera
E
: Characteristics and outcomes of patients with advanced cancer evaluated by a palliative care team at an emergency center. A retrospective study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
2016
;24:2287-2295.
2.
Elsayem
AF
,
Elzubeir
HE
,
Brock
PA
,
Todd
KH
.
Integrating palliative care in oncologic emergency departments: challenges and opportunities
.
World J Clin Oncol
.
2016
Apr
;
7
(
2
):
227
33
.
[PubMed]
2218-4333
3.
Tsai
SC
,
Liu
LN
,
Tang
ST
,
Chen
JC
,
Chen
ML
:
Cancer pain as the presenting problem in emergency departments: incidence and related factors.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
2010
;18:57-65.
4.
Delgado-Guay
MO
,
Kim
YJ
,
Shin
SH
,
Chisholm
G
,
Williams
J
,
Allo
J
, et al.
Avoidable and unavoidable visits to the emergency department among patients with advanced cancer receiving outpatient palliative care
.
J Pain Symptom Manage
.
2015
Mar
;
49
(
3
):
497
504
.
[PubMed]
0885-3924
5.
Wallace
EM
,
Cooney
MC
,
Walsh
J
,
Conroy
M
,
Twomey
F
.
Why do palliative care patients present to the emergency department? Avoidable or unavoidable?
Am J Hosp Palliat Care
.
2013
May
;
30
(
3
):
253
6
.
[PubMed]
1049-9091
6.
Carbo
A
,
Gupta
M
,
Tamariz
L
,
Palacio
A
,
Levis
S
,
Nemeth
Z
, et al.
Mobile Technologies for Managing Heart Failure: A Systematic Review and Meta-analysis
.
Telemed J E Health
.
2018
Apr
;
24
(
12
):
958
68
.
[PubMed]
1530-5627
7.
Mazilu
S
,
Blanke
U
,
Calatroni
A
,
Gazit
E
,
Hausdorff
JM
,
Tröster
G
.
The role of wrist-mounted inertial sensors in detecting gait freeze episodes in Parkinson’s disease
.
Pervasive Mobile Comput
.
2016
;
33
:
1
16
. 1574-1192
8.
Seiler
A
,
Klaas
V
,
Tröster
G
,
Fagundes
CP
.
eHealth and mHealth interventions in the treatment of fatigued cancer survivors: A systematic review and meta-analysis
.
Psychooncology
.
2017
Sep
;
26
(
9
):
1239
53
.
[PubMed]
1057-9249
9.
Merikangas
KR
,
Swendsen
J
,
Hickie
IB
,
Cui
L
,
Shou
H
,
Merikangas
AK
, et al.
Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder
.
JAMA Psychiatry
.
2018
Dec
.
[PubMed]
2168-6238
10.
Gresham
G
,
Schrack
J
,
Gresham
LM
,
Shinde
AM
,
Hendifar
AE
,
Tuli
R
, et al.
Wearable activity monitors in oncology trials: current use of an emerging technology
.
Contemp Clin Trials
.
2018
Jan
;
64
:
13
21
.
[PubMed]
1551-7144
11.
Giordano
FA
,
Welzel
G
,
Siefert
V
,
Jahnke
L
,
Ganslandt
T
,
Wenz
F
, et al.
Digital Follow-Up and the Perspective of Patient-Centered Care in Oncology: what’s the PROblem?
Oncology
.
2018
Dec
;
•••
:
1
7
.
[PubMed]
0030-2414
12.
Cox
A
,
Illsley
M
,
Knibb
W
,
Lucas
C
,
O’Driscoll
M
,
Potter
C
, et al.
The acceptability of e-technology to monitor and assess patient symptoms following palliative radiotherapy for lung cancer
.
Palliat Med
.
2011
Oct
;
25
(
7
):
675
81
.
[PubMed]
0269-2163
13.
Theile
G
,
Klaas
V
,
Tröster
G
,
Guckenberger
M
.
mHealth Technologies for Palliative Care Patients at the Interface of In-Patient to Outpatient Care: Protocol of Feasibility Study Aiming to Early Predict Deterioration of Patient’s Health Status
.
JMIR Res Protoc
.
2017
Aug
;
6
(
8
):
e142
.
[PubMed]
1929-0748
14.
Pavic
M
,
Theile
G
,
Guckenberger
M
,
Tröster
G
,
Klaas
V
.
EP-1684: mobile health technology in severely ill patients
.
Radiother Oncol
.
2018
;
127
:
S904
5
. 0167-8140
15.
Klaas
VC
,
Calatroni
A
,
Hardegger
M
,
Guckenberger
M
,
Theile
G
,
Tröster
G
.
Monitoring Patients in Ambulatory Palliative Care: A Design for an Observational Study
.
Cham
:
Springer International Publishing
;
2017
. pp.
207
14
.
16.
O’Brien
BC
,
Harris
IB
,
Beckman
TJ
,
Reed
DA
,
Cook
DA
.
Standards for reporting qualitative research: a synthesis of recommendations
.
Acad Med
.
2014
Sep
;
89
(
9
):
1245
51
.
[PubMed]
1040-2446
17.
Worster
B
,
Swartz
K
.
Telemedicine and Palliative Care: an Increasing Role in Supportive Oncology
.
Curr Oncol Rep
.
2017
Jun
;
19
(
6
):
37
.
[PubMed]
1523-3790
18.
Abernethy
AP
,
Herndon
JE
 2nd
,
Wheeler
JL
,
Day
JM
,
Hood
L
,
Patwardhan
M
, et al.
Feasibility and acceptability to patients of a longitudinal system for evaluating cancer-related symptoms and quality of life: pilot study of an e/Tablet data-collection system in academic oncology
.
J Pain Symptom Manage
.
2009
Jun
;
37
(
6
):
1027
38
.
[PubMed]
0885-3924
19.
Pinto
S
,
Caldeira
S
,
Martins
JC
.
e-Health in palliative care: review of literature, Google Play and App Store
.
Int J Palliat Nurs
.
2017
Aug
;
23
(
8
):
394
401
.
[PubMed]
1357-6321
20.
McCall
K
,
Keen
J
,
Farrer
K
,
Maguire
R
,
McCann
L
,
Johnston
B
, et al.
Perceptions of the use of a remote monitoring system in patients receiving palliative care at home
.
Int J Palliat Nurs
.
2008
Sep
;
14
(
9
):
426
31
.
[PubMed]
1357-6321
21.
Ferriolli
E
,
Skipworth
RJ
,
Hendry
P
,
Scott
A
,
Stensteth
J
,
Dahele
M
, et al.
Physical activity monitoring: a responsive and meaningful patient-centered outcome for surgery, chemotherapy, or radiotherapy?
J Pain Symptom Manage
.
2012
Jun
;
43
(
6
):
1025
35
.
[PubMed]
0885-3924
22.
Innominato
PF
,
Komarzynski
S
,
Palesh
OG
,
Dallmann
R
,
Bjarnason
GA
,
Giacchetti
S
, et al.
Circadian rest-activity rhythm as an objective biomarker of patient-reported outcomes in patients with advanced cancer
.
Cancer Med
.
2018
Sep
;
7
(
9
):
4396
405
.
[PubMed]
2045-7634
23.
Low
CA
,
Dey
AK
,
Ferreira
D
,
Kamarck
T
,
Sun
W
,
Bae
S
, et al.
Estimation of Symptom Severity During Chemotherapy From Passively Sensed Data: exploratory Study
.
J Med Internet Res
.
2017
Dec
;
19
(
12
):
e420
.
[PubMed]
1438-8871
24.
Wright
AA
,
Raman
N
,
Staples
P
,
Schonholz
S
,
Cronin
A
,
Carlson
K
, et al.
The HOPE Pilot Study: Harnessing Patient-Reported Outcomes and Biometric Data to Enhance Cancer Care
.
JCO Clin Cancer Inform
.
2018
Dec
;
2
(
2
):
1
12
.
[PubMed]
2473-4276
25.
El Shafie
RA
,
Weber
D
,
Bougatf
N
,
Sprave
T
,
Oetzel
D
,
Huber
PE
, et al.
Supportive Care in Radiotherapy Based on a Mobile App: Prospective Multicenter Survey
.
JMIR Mhealth Uhealth
.
2018
Aug
;
6
(
8
):
e10916
.
[PubMed]
2291-5222
26.
Kessel
KA
,
Vogel
MM
,
Schmidt-Graf
F
,
Combs
SE
: Mobile Apps in Oncology: A Survey on Health Care Professionals’ Attitude Toward Telemedicine, mHealth, and Oncological Apps.
2016
;18:e312.
27.
Vayena
E
,
Haeusermann
T
,
Adjekum
A
,
Blasimme
A
.
Digital health: meeting the ethical and policy challenges
.
Swiss Med Wkly
.
2018
Jan
;
148
:
w14571
.
[PubMed]
1424-3997
28.
Basch
E
,
Deal
AM
,
Dueck
AC
,
Scher
HI
,
Kris
MG
,
Hudis
C
, et al.
Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment
.
JAMA
.
2017
Jul
;
318
(
2
):
197
8
.
[PubMed]
0098-7484
29.
Denis
F
,
Lethrosne
C
,
Pourel
N
,
Molinier
O
,
Pointreau
Y
,
Domont
J
, et al.
Overall survival in patients with lung cancer using a web-application-guided follow-up compared to standard modalities: results of phase III randomized trial
.
J Clin Oncol
.
2016
;
34
15_suppl
:
LBA9006
9006
. 0732-183X
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.