The synchronous occurrence of breast and ovarian cancers within individual omental metastases has not been reported in the available medical literature. We report such a finding in a patient with previously diagnosed invasive lobular carcinoma of the right breast. After 5 years of surveillance and disease-free interval, there was development of ovarian cancer, ascites and peritoneal metastases. Ultrasound-guided biopsy of a peritoneal metastasis confirmed dual histology from breast and ovarian carcinoma. Despite the presence of a prolonged disease-free survival from the primary breast cancer, the subsequent finding of advanced ovarian cancer highlights the potential diagnostic and therapeutic dilemmas which persist in the management of these patients.

Miki Y, Swensen J, Shattuck-Eidens D, et al: A strong candidate for breast and ovarian cancer susceptibility gene BRCA-1. Science 1994;266:66–71.
Wooster R, Neuhausen SL, Mangion J, et al: Localization of a breast cancer susceptibility gene, BRCA-2 to chromosome 13q12-13. Science 1994;265:2088–2090.
Ford D, Easton DF: The genetics of breast and ovarian cancer. Br J Cancer 1995;72:805–812.
Risch HA, McLaughlin JR, Cole DEC, et al: Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 2001;68:700–710.
Ford D, Easton DF, Bishop DT, et al: Risks of cancer in BRCA1 mutation carriers: Breast Cancer Linkage Consortium. Lancet 1994;343:692–695.
Suris-Swartz PJ, Schidkraut JM, Vine MF, Hertz-Picciotto I: Age at diagnosis and multiple primary cancers of the breast and ovary. Breast Cancer Res Treat 1996;41:21–29.
Lamovec J, Bracko M: Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol 1991;48:28–33.
Hennigan CA, Bur M, Conovan JT: Fine-needle aspiration in the diagnosis of metastatic ovarian cancer to the breast. Gynecol Oncol 1997;64:533–540.
Krishnan EU, Phillips AK, Randell A, et al: Bilateral metastatic inflammatory carcinoma in the breast from primary ovarian cancer. Obstet Gynecol 1980;55:S94–S96.
Kuo DY, Jones J, Fields AL, Runowicz CD, Goldberg GL: Endometrioid adenocarcinoma of the ovary and long term tamoxifen therapy, a coincidence or a cause for concern? Eur J Gynaecol Oncol 1997;18:457–460.
Cohen I, Beyth Y, Tepper R, Shapira J, Figer A, Cordoba M, Yigael D, Altaras MM: Ovarian tumours in postmenopausal breast cancer patients treated with tamoxifen. Gynaecol Oncol 1996;60:54–58.
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