3% of human cancers are renal cell carcinomas (RCC). The most common chromosome abnormality found in this tumor is loss of heterozygosity (LOH) on the short arm of chromosome 3, which suggests that there must be one or more tumor suppressor genes between 3p14 and 3p21 near the VHL gene which play a relevant role in renal cancer development. DNA from normal and tumor tissue from 40 patients at various stages of RCC was analyzed for LOH at three microsatellites mapped to 3p (3p14.1–14.3; 3p21.2–21.3 and 3p25) by polymerase chain reaction). 42.5% of the tumors studied showed LOH on at least one locus. 30% showed LOH on only one locus; 5% on two loci and 7.5% on the three loci tested. LOH occurred only on nonpapillary tumors (p = 0.03). Interestingly, all the tumors with LOH on 3p21 were ≥25 mm (p = 0.04; relative risk 1.76, confidence interval: 1.3–2.3).

Kovacs G, Frisch S: Clonal chromosome abnormalities in tumour cells from patients with sporadic renal cell carcinomas. Cancer Res 1989;49:651–659.
Morita R, Ishikawa J, Tsutsumi M, Hikiji K, Tsukada Y, Kamidono S, Maeda S, et al: Alleotype of renal cell carcinoma. Cancer Res 1991;51:820–823.
Anglard P, Tory K, Brauch H, Weiss GH, Latif F, Merino MJ, Lerman MI, et al: Molecular analysis of genetic changes in the origin and development of renal cell carcinoma. Cancer Res 1991;51:1071–1077.
Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, et al: Three distinct regions involved in 3p deletion in human lung cancer. Oncogene 1992;7::445–449.
Brauch H, Pomer S, Hieronymus T, Schadt T, Lohrke H, Komotowski D: Genetic alterations in sporadic renal-cell carcinoma: Molecular analysis of tumour suppressor gene harbouring chromosomal regions 3p, 5q and 17p. World J Urol 1994;12:162–168.
Sato T, Tanigami A, Yamakwa K, Akiyama F, Kasumi F, Sakamoto G, Nakamura Y: Allelotype of breast cancer: Cumulative allele losses promote tumour progression in primary breast cancer. Cancer Res 1990;50:7184–7189.
Devilee P, van den Broek M, Kuipers-Djkshoorn N, Kolluri R, Khan PM, Pearson PC, Cornelisse CJ: At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma. Genomics, 1989;5:554–560.
Sato T, Saito H, Morita R, Koi S, Lee JH, Nakamura Y: Allelotype of human ovarian cancer. Cancer Res 1991;51:5118–5122.
Zheng J, Robinson WR, Ehlen T, Yu MC, Dubeau L: Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6 and 11 and HER-2/neu gene amplification. Cancer Res 1991;51:4045–4051.
Yokota J, Tsukada Y, Nakajima T, Gotoh M, Shimosato Y, Mori N, Tsunokawa Y, et al: Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. Cancer Res 1989;49:3598–3601.
Lubinski J, Hadaczek P, Podoloski J, Toloczko A, Sikorski A, McCue P, Druck T, et al: Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res 1994;54:3710–3713.
Yamakawa K, Morita R, Takahashi E, Hori T, Ishikawa J, Nakamura Y: A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 1991;51:4707–4711.
Van der Hout AH, van der Vlies P, Wijmenga C, Li FP, Oosterhuis JW, Buys CH: The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB. Genomics 1991;11:537–542.
Foster K, Crossey PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, et al: Molecular genetic investigation of sporadic renal cell carcinoma: Analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. Br J Cancer 1994;69:230–234.
Brauch H, Tory K, Kotler F, Gazdar AF, Pettengill OS, Johson B, Graziano S, et al: Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer. Genes Chromosom Cancer 1990;1:240–246.
Van den Berg A, Hulsbeek MMF, de Jong D, Kok K, Veldhuis PM, Roche J, Buys CH: Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis. Genes Chromosom Cancer 1996;15:64–72.
Störkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG, et al: Classification of renal cell carcinoma. Cancer 1997;80:987–989.
Orikasa K, Orikasa S, Horii A: Identification of a 700-kb region of common allelic loss in chromosome bands 3p14.3–3p21.1 in human renal cell carcinoma. Cancer Genet Cytogenet 1998;104:104–110.
Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS: Hereditary renal-cell carcinoma associated with a chromosomal translation. N Engl J Med 1979;301:592–595.
Zbar B, Brauch H, Talmadge C, Linehan M: Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 1987;327:721–724.
Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, et al: Mutations of the VHL tumour suppresser gene in renal carcinoma. Nat Genet 1994;7:85–90.
Van den Berg A, Dijkhuizen T, Draaijers TG, Hulsbeek MM, Maher ER, Van den Berg E, Storkell S, et al: Analysis of multiple renal cell adenomas and carcinomas suggests allelic loss at 3p21 to be a prerequisite for malignant development. Genes Chromosom Cancer 1997;19:228–232.
Clifford SC, Prowse AH, Affara NA, Buys CH, Maher ER: Inactivation of the Von Hippel- Lindau tumour suppresser gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumorigenesis. Gene Chromosome Cancer 1998;22:200–209.
Maestro ML, Izquierdo L, S-Pernaute A, Sanz MT, González S, Torres A, del Barco V, et al: Relevance of heterozygosity in chromosome 3p in non small cell lung carcinoma as prognostic factor. Med Clin, accepted.
Mehle C, Lindblom A, Ljungberg B, Stenling R, Roos G: Loss of heterozygosity at chromosome 3p correlates with telomerase activity in renal carcinoma. Int J Oncol 1998;13:289–295.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.