The medical files of 14 patients with primary brain and spine sarcomas were retrospectively reviewed. Ten patients had primary brain sarcomas and 4 primary spinal sarcomas. The tumors probably originated in the brain substance or blood vessels, in the meninges or in the inner aspect of the skull. The spinal tumors originated in the nerve roots of the cauda equina and in the spinal substance or blood vessels. The most common type was angiosarcoma. Removal of the brain tumors was performed in 95% of the patients. Radiotherapy was delivered to 6 patients with brain sarcomas and to all patients with primary spinal sarcomas. Metastatic disease to the lung or pleural effusion was evident in 2 patients who underwent total removal of their tumors followed by radiation therapy.

Brennan MF, Casper ES, Harrison LB: Soft tissue sarcoma; in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology, ed 5. Philadelpha, Lippincott-Raven, 1997, chap 38, pp 1731–1852.
Malawer MM, Link MP, Donaldson SS: Sarcomas of bone; in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Philadelphia, Lippincott, 1993, pp 1509–1566.
Russell DS, Rubinstein LJ: Pathology of Tumours of the Nervous System, ed 5. London, Arnold, 1989, pp 449–532.
Zulch KJ: Tumors of the meningeal and related tissues; in Zulch KJ (ed): Brain Tumors. Berlin, Springer, 1986, pp 357–393.
Zulch KJ: Local extension from regional tumors; in Zulch KJ (ed): Brain Tumors. Berlin, Springer, 1986, pp 474–489.
Smith MM; Thompson JE, Castillo M: Radiation-induced cerebral osteogenic sarcoma. Am J Radiol 1996;167:1067.
Iwasaki K, Kikuchi H, Miyatake SI, Kondo S, Oda Y: Establishment of a new cell line derived from a human gliosarcoma. Neurosurgery 1992;30:228–235.
Ron E, Modan B, Boice JD, Alfandary E, Stovall M, Chetrit A, Katz L: Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 1989;319:1033–1039.
Chang SM, Barker FG, Larson DA, Bollen AW, Prados MD: Sarcomas subsequent to cranial irradiation. Neurosurgery 1995;36:685–690.
Pomeranz SJ, Hawkins HH, Towbin R, Lisberg WN, Clark RA: Granulocytic sarcoma (chloroma): CT manifestations. Radiology 1985;155:167–170.
Wright DH, Hise JH, Bauserman SC, Naul LG: Intracranial granulocytic sarcoma: CT, MR, and angiography. J Comput Assist Tomogr 1992;16:487–489.
Slowinski J, Adamek D, Krygowaska-Wajs A, Rudzinska M, Kaluza J: Sarcomatosis of the leptomeninges, brain, and spinal cord coexisting with von-Recklinghausen’s neurofibromatosis. A case report and a review of the literature. Folia Neuropathol 1995;33:135–140.
Tierney JF, Mosseri V, Stewart LA, Souhami RL, Parmar MKB: Adjuvant chemotherapy for soft-tissue sarcoma: Review and meta-analysis of the published results of randomised clinical trials. Br J Cancer 1995;72:469–475.
Mena H, Ribas JL, Enzinger FM, Parisi JE: Primary angiosarcoma of the central nervous system. Study of eight cases and review of the literature. J Neurosurg 1991;75:73–76.
Rushing EJ, Armonda RA, Ansari Q, Mena H: Mesenchymal chondrosarcoma: A clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system. Cancer 1996;77:1884–1891.
Dropcho EJ, Allen JC: Primary intracranial rhabdomyosarcoma: Case report and review of the literature. J Neurooncol 1987;5:139–150.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.