The immunolocalization of the pl6 and cdk4 proteins was investigated in 65 retinoblastoma gene product (pRB)-positive and 20 pRB-negative breast carcinomas. These proteins were expressed in similar lesions in 84.6% of the pRB-positive and 100% of the pRB-negative carcinomas. Diffuse expression of pl6 was observed in 73.8 and 70.0% of the pRB-positive and -negative cases, respectively. cdk4 and p 16 expression was significantly more heterogeneous in tumors of larger sizes and/or at higher stages. These findings suggest that p 16 can be induced regardless of pRB status and Rb gene function in primary breast carcinoma and that it modulates the cell cycle progression in association with cdk4.

Keywords:
pl6, Cyclin-dependent kinase 4, Retinoblastoma gene product, Immunohistochemistry, Breast carcinoma
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© 1997 S. Karger AG, Basel
1997
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