The modified steroidal alkylating agent, 3β-hydroxy-13α-amino-13,17-seco-5α-androstane-17-oic-13,17-lactam[p-[bis(2-chloroethyl)amino]-phenyl]acetate showed excellent activity in treatment of three murine solid tumors. Colon 26-bearing CD2F1 mice lived twice as long as controls with tumor free survivors at the end of the 70-day observation period. CD8F1 mammary tumor growth was suppressed greater than 90% compared to controls. B16 melanoma-bearing B6D2F1 mice lived 50% longer than controls. This agent had previously been shown to be active in treatment of the Theagenion-Bahner angiosarcoma, the T8 Guerin tumor, LI210 leukemia and P388 leukemia.

Keywords:
Murine solid tumors, Stereoidal alkylating agent
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© 1982 S. Karger AG, Basel
1982
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