Mammary adenocarcinoma were induced by an oral administration of 7,12-dimethylbenz(α)anthracene to Sprague-Dawley (SD) rats. Antibodies to the pooled tumor cells produced in Wistar rats were made tumor-specific by successive absorption with pooled SD red blood cells, normal mammary cells, and normal serum. Such antibodies were found to be cytotoxic to the original pooled tumor cells as well as to the pools prepared from other animals, thus suggesting the existence of antigenic cross-reactivity in such hydrocarbon-induced tumors. This activity was lost when the anti-tumor antisera were heated at 56°C for 30 min but reconstituted (although not to the original level) on addition of fresh guinea pig complement. The cytotoxic activity was found to be localized in both the IgM and IgG fractions, the former being more efficient than the latter. In addition, the tumors pretreated with specific antibody were found to be nontransplantable as compared with the 90 percent transplantability of untreated tumors.

Keywords:
Antibody-mediated, Antigens, Cytotoxicity, Dimethylbenz(α)anthracene, Mammary, TATA, Transplantation, Tumor
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© 1974 S. Karger AG, Basel
1974
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