The relationship between untreated, irradiated and heat-killed Ehrlich ascites cells and peritoneal macrophages was studied. At different time intervals, peritoneal washing fluids were observed with a dark field-equipped microscope and were used to prepare Leighton tubes. Histological preparations were made from mesenteric lymph nodes. While heat-killed cancer cells were immediately phagocytized by peritoneal macrophages, the phagocytosis of irradiated cancer cells started only after about 72 h. Pyroninophylic lymphoblasts in mesenteric lymph nodes appeared earlier in animals inoculated with heat-killed ascites cells. No phagocytosis by peritoneal macrophages and no histological modification in lymph nodes were observed in animals injected with untreated cancer cells. Mechanisms by which living homologous cancer cells can avoid phagocytosis by macrophages are discussed.

Keywords:
Neoplastic cell and macrophage interaction, Ehrlich ascites cells, Peritoneal macrophage phagocytosis, Cellular recognition
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© 1972 S. Karger AG, Basel
1972
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