Having previously stressed quantita tive aspects of inhibition and the definition of the streptomycin induced response in anurans, the present study attempts a macroscopic and histologic analysis of inhibition of limb regeneration in the adult newt, D. viridescens, by streptomycin. This study confirmed earlier results that epidermal proliferation is not inhibited by the drug except in the highest concentrations; however, blastemal elements are markedly altered. It is thought that one of the important effects of streptomycin is its binding irreversibly to the ribosomal surface, and causing translational errors resulting in the production of inoperative proteins. The results suggest that the production of the blastemal mass and differentiation represent separate, partially synchronous, and coterminal processes. It may well be that the teratology seen in this experiment results not only from the production of missense or inoperative proteins by streptomycin but also from the unusual molecular ecology of the blastemal environment created by the abnormal dedifferentiation where fully dedifferentiated cells lie in close proximity to undifferentiated elements. Indirectly, this study has called attention to the unresolved problem of exactly which cells contribute to blastemal cell populations.

Keywords:
Limb regeneration, Cell differentiation, Streptomycin teratogenesis, Diemictylus viridescens limbs
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© 1972 S. Karger AG, Basel
1972
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