...Peter J. Darby; Chiu-Yin Kwan; Edwin E. Daniel The study of the relative roles of the plasma membrane (PM) and the sarcoplasmic reticulum (SR) Ca 2+ pumps in the regulation of internal Ca 2+ has been limited in the past due in part to the lack of selective inhibitors for either Ca 2+ pump. Recently...

... whether tBuBHQ also acts as a Ca 2+ pump inhibitor of sarcoplasmic reticulum (SR) in vascular smooth muscle. tBuBHQ elicited a slowly developing and gradually decreasing contraction which was dependent on extracellular Ca 2+ . We utilize the phenylephrine (PE)-induced transient contractile response in Ca...