... in mediating sPLA 2 -IIA secretion. Moreover, KA-induced sPLA 2 -IIA secretion is dependent on Ca 2+ and protein kinase C. Together, these findings provide evidence of a link between glutamate receptors and regulated sPLA 2 secretion in neurons that may play an important role in synaptic plasticity, pain...

...Yanbo Zhang; Kerui Gong; Weihua Zhou; Guo Shao; Sijie Li; Qing Lin; Jingjin Li Protein kinase C (PKC) has been widely reported to participate in somatic pain; however, its role in visceral pain remains largely unclear. Using a colon inflammatory pain model by intracolonic injection of formalin...

... to in the content or advertisements. Neuromuscular transmission Adenosine A 2A receptors Muscarinic M 1 receptors Protein kinase A Protein kinase C Ca v 1 (L-type) channels Acetylcholine release Original Paper Neurosignals 2005;14:262 272 DOI: 10.1159/000088642 Received: May 19, 2005 Accepted after...

... Protein kinase C Review Neurosignals 2005;14:46 60 DOI: 10.1159/000085385 Received: January 28, 2005 Accepted after revision: March 1, 2005 Multifunctional Activities of Green Tea Catechins in Neuroprotection Modulation of Cell Survival Genes, Iron-Dependent Oxidative Stress and PKC Signaling Pathway...

... that ultimately drive a cell to its demise. We present for consideration several critical cellular pathways modulated by EPO that involve Janus kinase 2 (Jak2), the serine-threonine kinase Akt, forkhead transcription factors, glycogen synthase kinase-3β (GSK-3β), cellular calcium, protein kinase C, caspases...

...) hypersensitivity in an individual animal, and the changes of spinal neurons are likely to be responsible for the production of these pain-related behaviors. In this study, we examined the roles of spinal protein kinase C (PKC) and protein kinase A (PKA) in the BV-induced different types of pain...

... messenger-mediated phosphorylation and dephosphorylation of specific protein targets is a mechanism capable of regulating diverse cellular functions in the carotid body during acute and chronic stimulation. Catecholamine release GAP-43 Nitric oxide Oncogene Protein kinase C 29 11 1999...

...Akira Warashina Modulatory effects of the activation of either protein kinase C (PKC) by phorbol 12,13-dibutyrate (PDBu) or protein kinase A (PKA) by forskolin on stimulant-evoked secretory processes in the perfused rat adrenal medulla were studied. PDBu or forskolin was applied during repetitive...

.... It has been suggested for a long time that the histamine release (HR) from these cells is closely related to protein kinase C (PKC) activity. However, the distinct role of PKC with its large variety of isozymes in different cell types and the actions of these isozymes in HR still remain unclear...

..., instructions or products referred to in the content or advertisements. Differential actions of goldfish GnRHs GTH release GH release Voltage-sensitive Ca 2+ channels Na + involvement Cyclic AMP Arachidonic acid Inositol phosphates Protein kinase C Calmodulin BioloqicAl SiqiNAls Biol Signals...

... resembled those treated with the protein kinase C (PKC) agonist phorbol myristate acetate (PMA, 10 –7 M). The intracellular concentration of [Met 5 ]-enkephalin (ME) was significantly increased in staurosporine-treated cells whereas the secretion of ME into the medium was significantly less than that from...

... to a cholera toxin- or pertussis toxin-insensitive GTP-binding protein, possibly a G q class one, may play a role in the genesis of vascular contraction in response to stretch. Actuation of protein kinase C may affect more strongly the maintenance phase of stretch-induced contraction through the change in Ca 2...

...S.K. Kong; Y.M. Choy; C.Y. Lee The role of protein kinase C (PKC) in the signal transduction process when macrophage cells were stimulated by the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (fMLP) was investigated in the cell line PU5-1.8. Addition of fMLP to PU5-1.8 cells induced...

...) and calmidazolium (a calmodulin antagonist) inhibited both the secretion of ME and the increase in proENK mRNA levels induced by pertussis toxin, while the intracellular calcium antagonist dantrolene and the protein kinase C inhibitors sphingosine and H7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine] were...

... of DNA synthesis, and PKC may be functioning as a modulator with dual action at least on the level of ion conductance. 10 10 1991 Signal transduction Macrophage Membrane depolarization Intracellular free Ca 2+ Protein kinase C 0 - R I G I N A L P A P E R Biol Signals 1992;1:12-22...