...Bruno P. Carreira; Maria Inês Morte; Ana Sofia Lourenço; Ana Isabel Santos; Ângela Inácio; António F. Ambrósio; Caetana M. Carvalho; Inês M. Araújo Nitric oxide (NO) is an important inflammatory mediator involved in the initial boost in the proliferation of neural stem cells following brain injury...

... examined and the mechanisms were investigated by inhibiting nitric oxide synthase and ATP-sensitive potassium channels. As a result, 0.5 µg/ml lipopolysaccharide mainly caused inhibitory responses in both the frequency and the output intensity, while 5 µg/ml lipopolysaccharide caused an early frequency...

... cells and enhanced the production of nitric oxide (NO). Transcription of NO synthase (NOS) 1–3 and PGC-1a (a key regulator of mitochondrial biogenesis) was activated. In vivo, copper impaired the NMDA-mediated regulation of glutamate in the brain, increased the production of NO and enhanced markedly...

.... Objective: We aimed to investigate the significance of nitric oxide (NO)-mediated neuronal death during elderly aging and in ALS. To do so, the concentration of ADMA, an endogenous NO synthase inhibitor in the cerebrospinal fluid (CSF), was determined in neurologically normal controls and in patients...

...Ming Chen; Hong-Yu Sun; Shu-Ji Li; Manas Das; Ji-Ming Kong; Tian-Ming Gao Nitric oxide (NO) and p38 have been shown to be involved in the ischemia/hypoxia-induced neuronal injury. In this study, we examined the activation patterns of mitogen-activated protein kinases and explored the relationship...

...Kenny K.K. Chung Nitric oxide (NO) is an important signaling molecule that controls a wide range of biological processes. One of the signaling mechanisms of NO is through the S-nitrosylation of cysteine residues on proteins. S-nitrosylation is now regarded as an important redox signaling mechanism...

...Britta Püttmann; Eva-Maria Gerlach; Mark Krüger; Dieter Blottner It has previously been shown that skeletal myotubes express nitric oxide synthase (NOS) and produce and release NO signals. NOS is also part of agrin-induced acetylcholine receptor aggregations on myotubes. As nerve-muscle...

... stimulation of gene expression of neutralizing enzymes. Prostaglandins and nitric oxide are important neuroimmunomodulators in digestive physiology and different studies have indicated that the protective properties of melatonin may be explained by prostaglandin and/or nitric oxide mechanisms. The aim...

...Ronald R. Fiscus Our current understanding of nitric oxide (NO), cyclic GMP (cGMP) and protein kinase G (PKG) signaling pathways in the nervous systems has its origins in the early studies conducted on vascular tissues during the late 1970s and early to mid-1980s. The pioneering research...

...Masato Nagahama; Reiji Semba; Masako Tsuzuki; Eiko Aoki L -Arginine is a precursor of nitric oxide (NO) that may be involved in neuronal activity in the gastrointestinal tract. It is known that NO is formed from L -arginine by NO synthase which is localized in neurons in the enteric nervous system...

...Jorge Boczkowski; Constanza L. Lisdero; Sophie Lanone; Maria Cecilia Carreras; Michel Aubier; Juan Jose Poderoso Peroxynitrite anion (ONOO – ) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse...

...Pedram Ghafourifar; Urs Bringold; Sabine D. Klein; Christoph Richter Nitric oxide (NO) exerts a wide range of its biological properties via its interaction with mitochondria. By competing with O 2 , physiologically relevant concentrations of NO reversibly inhibit cytochrome oxidase and decrease O 2...

... in the morphologically similar small intensely fluorescent cells of the superior cervical sympathetic ganglia. (2) Nitric oxide production and efferent inhibition in the chemosensory tissue is reduced in the presence of the specific tyrosine kinase inhibitor, lavendustin A. (3) Hypoxia-induced catecholamine release from...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Monoamines Acetylcholine GABA Glutamic acid Histamine Opioids Nitric oxide Interleukin-1 Interleukin-2 Interleukin...

.... The concentration-relaxing response curves for isoproterenol (ISO) and norepinephrine (NE) in the presence of phentolamine were shifted to the right, and the maximal relaxations were reduced by removing the endothelium. Nitric oxide synthase inhibitor L -N G -nitro-arginine reduced the maximal relaxation induced...

...Yoshihiko Oyanagui; Sachio Sato Endogenous nitric oxide (NO, endothelium-derived relaxing factor) was stimulatory for histamine- and suppressive for serotonin-induced paw edema of mice. This action was mediated by guanosine 3'',5''-cyclic monophosphate production. Local injection of superoxide...