...), but mostly fail in PMS. Pregabalin (Lyrica®) is prescribed to MS patients to treat neuropathic pain. Mechanistically, it targets voltage-dependent Ca 2+ channels and reduces harmful neuronal hyperexcitation in mouse epilepsy models. Studies suggest that GABA analogues like pregabalin exert neuroprotective...

... neurotoxicity Neuroprotection Apoptosis Neuroglobin Estrogen receptor Original Paper Neurosignals 2010;18:223 235 DOI: 10.1159/000323906 Received: November 17, 2010 Accepted: December 28, 2010 Published online: February 18, 2011 17 -Estradiol A New Modulator of Neuroglobin Levels in Neurons: Role...

... in performing neuroprotective and neurotrophic activities. 18 7 2008 © 2008 S. Karger AG, Basel 2008 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Glia Neurotrauma Astrocyte Gliosis Neuroprotection Inflammation Brain edema Controlled cortical impact, synaptic Neurosignals 2008;16:154...

... NMDA receptor functions. The present data thus provide detailed cellular and molecular mechanisms to explain our previous findings of amelioration of motor symptoms in a rat model of Parkinson’s disease. More importantly, application of ANR1 was also found to display neuroprotective effects of striatal...

... makes them valuable source of novel lead compounds against therapeutic targets that are newly discovered by genomics, proteomics, and high-throughput screening. 17 09 2004 20 09 2004 10 6 2005 Inflammation Neuroglia Neurodegenerative disease Flavonoid Neuroprotection...

... neuroprotective drugs that would prevent the progression of neurodegeneration. Tea flavonoids (catechins) have been reported to possess potent iron- chelating, radical-scavenging and anti-inflammatory activities and to protect neuronal death in a wide array of cellular and animal models of neurological diseases...

... mitochondria, and interfere with APP metabolism. Antagonizing effects on NMDA receptors and potassium currents may contribute to the neuroprotection as well. It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. The therapeutic effects of HupA on AD or VD...

... that follows spontaneous repetitive seizures. Kainic acid Chronic temporal lobe epilepsy model Glutamic acid decarboxylase Choline acetyltransferase Somatostatin Cortical regions Neuroprotection Neurodegeneration Epileptogenesis Brain Rat 7 04 2004 19 08 2004 23 12 2004 ©...

... nervous system (CNS), little is known about the physiological role of TACE, but some important pathophysiological functions have been reported recently, with both neurotoxic and neuroprotective repercussions. This article discusses and reviews the main contributions to this field of investigation...

... fragmentation Neuroprotection Neurodegenerative diseases Alzheimer’s disease Aging Nitric oxide Natriuretic peptides Neurotrophic factors Cyclic nucleotide-gated cation channels Phosphodiesterases © 2002 S. Karger AG, Basel 2002 Copyright / Drug Dosage / Disclaimer Copyright: All rights...