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Keywords: Neurodegeneration
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Journal Articles
Neurosignals (2012) 20 (4): 265–280.
Published Online: 23 February 2012
... between the ER and mitochondria in neurodegeneration, we treated SH-SY5Y human neuroblastoma cells with thapsigargin and tunicamycin, two inducers of ER stress, and atrazine, a promoter of mitochondrial stress. Each pharmacological agent caused mitochondrial dysfunction, which was characterized by reduced...
Journal Articles
Journal Articles
Neurosignals (2007) 16 (1): 75–84.
Published Online: 05 December 2007
... we describe autophagy and review the evidence suggesting that impairment of autophagy contributes to the initiation or progression of age-related neurodegeneration. We also review recent evidence indicating that autophagy may be exploited to remove toxic protein species, suggesting novel strategies...
Journal Articles
Neurosignals (2007) 16 (1): 63–74.
Published Online: 05 December 2007
.... Hsp104 Prion Amyloid AAA+ protein Huntington’s disease Neurodegeneration Neurosignals 2008;16:63 74 DOI: 10.1159/000109760 Published online: December 5, 2007 Hsp104: A Weapon to Combat Diverse Neurodegenerative Disorders James Shorter Department of Biochemistry and Biophysics, University...
Journal Articles
Neurosignals (2007) 16 (1): 52–62.
Published Online: 05 December 2007
... Neurodegeneration Parkinson’s disease Huntington’s disease Friedreich’s ataxia Niemann-Pick disease High-throughput screening Neurosignals 2008;16:52 62 DOI: 10.1159/000109759 Published online: December 5, 2007 Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us about Neurodegenerative Disease...
Journal Articles
Neurosignals (2006) 15 (6): 307–313.
Published Online: 27 September 2007
... in the regulation of different cellular and physiological functions. However, deregulation of S-nitrosylation has also been linked to various human diseases such as neurodegenerative disorders. Nitrosative stress has long been considered as a major mediator in the development of neurodegeneration, but the molecular...
Journal Articles
Neurosignals (2006) 15 (1): 1–12.
Published Online: 04 July 2006
... of Biological Sciences, Nanyang Technological University, Singapore, and bMedical Center for Translational Research, Osaka University Hospital, Suita, Osaka, Japan Key Words Alzheimer s disease Apoptosis Nerve growth factor Neurodegeneration Neurotrophin Neural stem cells Abstract The protein family...
Journal Articles
Neurosignals (2005) 14 (1-2): 46–60.
Published Online: 10 June 2005
... neuroprotective drugs that would prevent the progression of neurodegeneration. Tea flavonoids (catechins) have been reported to possess potent iron- chelating, radical-scavenging and anti-inflammatory activities and to protect neuronal death in a wide array of cellular and animal models of neurological diseases...
Journal Articles
Neurosignals (2004) 13 (6): 290–297.
Published Online: 23 December 2004
... Cortical regions Neuroprotection Neurodegeneration Epileptogenesis Brain Rat Original Paper Neurosignals 2004;13:290 297 DOI: 10.1159/000081964 Received: April 7, 2004 Accepted after revision: August 19, 2004 Choline Acetyltransferase, Glutamic Acid Decarboxylase and Somatostatin in the Kainic Acid...
Journal Articles
Neurosignals (2003) 12 (4-5): 215–220.
Published Online: 18 December 2003
... of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering the phosphorylation state of cytosolic and cytoskeletal proteins and, possibly, through the induction of cell cycle regulators. The present paper reviews these findings and proposes new perspectives...