...: Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are beneficial in relapsing MS (RMS...

...Katrin Anne Becker; Ramona Halmer; Laura Davies; Brian D. Henry; Regan Ziobro-Henry; Yann Decker; Yang Liu; Erich Gulbins; Klaus Fassbender; Silke Walter Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several...

... changes in neural gene expression and discovery of signalling pathways within this complex biological network. The lack of suitable and sufficient human CNS tissue along with its inherent variability means that diverse animal models of both multiple sclerosis and neurotrauma are vital for examining...

... development and pathological course of human multiple sclerosis. All three receptors and their ligands, Gas6 (growth arrest-specific gene 6) and protein S, are expressed in the central nervous system (CNS), including in oligodendrocytes, the myelin-producing cell of the CNS. Recent studies have shown...

...Jun Guo; Hongzeng Li; Caiyong Yu; Fangfang Liu; Yanling Meng; Weidong Gong; Hao Yang; Xuefeng Shen; Gong Ju; Zhuyi Li; Jian Wang It has been reported that autoimmune inflammatory processes in human multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), may...