... blotting and electron microscopy and analyzed the effect of newly synthesized, mitochondria-targeted, Kv1.3 inhibitors on the induction of cell death in these cells. Finally, we performed in vivo studies on glioma bearing mice. Results: Here, we report that Kv1.3 is expressed in mitochondria of human...

... between the ER and mitochondria in neurodegeneration, we treated SH-SY5Y human neuroblastoma cells with thapsigargin and tunicamycin, two inducers of ER stress, and atrazine, a promoter of mitochondrial stress. Each pharmacological agent caused mitochondrial dysfunction, which was characterized by reduced...

... mitochondria, and interfere with APP metabolism. Antagonizing effects on NMDA receptors and potassium currents may contribute to the neuroprotection as well. It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. The therapeutic effects of HupA on AD or VD...

... and the release of cyto c. Treating cells with antimycin A alone could not induce a reduction in ΔΨm nor a release of cyto c. Taken together, our results indicate that TNF induced damage in mitochondria in L929 cells. Our data also show that an increase in the production of O 2 – · was important in the TNF...

...Jingxiang Bai; Arthur I. Cederbaum Mitochondria dysfunction induced by reactive oxygen species (ROS) is related to many human diseases and aging. In physiological conditions, the mitochondrial respiratory chain is the major source of ROS. ROS could be reduced by intracellular antioxidant enzymes...

...Axel Kowald Mitochondria are not only the main source of energy for most eukaryotic cells, but also the main source of free radicals. These reactive molecules can damage all components of a cell such as membranes, proteins and DNA. Therefore they have long been suspected to be involved...

... Aging Mitochondria Alzheimer’s disease © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical...

...Roberta A. Gottlieb Apoptosis is a coordinated sequence of events culminating in the death of the cell. Many of these biochemical processes are regulated by the mitochondria, including the release of proapoptotic molecules in addition to the caspase-activating cofactor, cytochrome c. Pro...

.... Friedreich’s ataxia Genetics Mitochondria Oxidative stress Iron metabolism Cardiomyopathy Magnetic resonance spectroscopy Metabolism Biol Signals Recept 2001;10:263 270 Mitochondrial Dysfunction in Friedreich s Ataxia Raffaele Lodia Doris J. Taylorb Anthony H.V. Schapirac, d aDipartimento di Medicina...

... with Parkinson’s disease, CoQ 10 is able to attenuate the MPTP-induced loss of striatal dopaminergic neurons. 24 5 2001 Apoptosis Dopaminergic neurons Ubiquinone Ubiquinol Complex I Mitochondria Parkinson’s disease © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage / Disclaimer...

... in the pathogenesis of a variety of cardiovascular diseases, including heart failure, myocardial infarction and atherosclerosis. Recently, it has become evident that mitochondria play important role in the signaling machinery of apoptotic cell death by releasing several apoptotic factors such as cytochrome c...

... that antioxidant enzymes in mitochondria may be responsible for the regulation of cytochrome c release and apoptotic cell death. This paper examines the current state of knowledge regarding the role of mitochondrial antioxidant enzymes, especially phospholipid hydroperoxide glutathione peroxidase. A model...

... Mitochondria W Respiration Abstract Peroxynitrite anion (ONOO ) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous...

...Sigune Schmidt; Andreas Strub; Wolfgang Voos The biogenesis of mitochondria requires the translocation of most mitochondrial proteins across two biological membranes. Mitochondrial preproteins are synthesized in the cytosol carrying targeting information, that is recognized by specific receptor...

...Max Dolder; Silke Wendt; Theo Wallimann The creatine/phosphocreatine circuit provides an efficient energy buffering and transport system in a variety of cells with high and fluctuating energy requirements. It connects sites of energy production (mitochondria, glycolysis) with sites of energy...

... of Mitochondrial Superoxide Generation Ching K. Chow Graduate Center for Nutritional Sciences, and Kentucky Agricultural Experiment Station, University of Kentucky, Lexington, Ky., USA Key Words Vitamin E W Mitochondria W Superoxide W Hydrogen peroxide Abstract The mitochondrion is the greatest source, as well...

...Pedram Ghafourifar; Urs Bringold; Sabine D. Klein; Christoph Richter Nitric oxide (NO) exerts a wide range of its biological properties via its interaction with mitochondria. By competing with O 2 , physiologically relevant concentrations of NO reversibly inhibit cytochrome oxidase and decrease O 2...

.... On the other hand, if mitochondrial production of ROS supplies a remarkable contribution to exercise-induced oxidative stress, mitochondria should be a primary target of oxidative damage. Unfortunately, there are controversial reports concerning the exercise effects on structural and functional characteristics...