...H.G.T. Blaauwgeers; P.A.E. Sillevis Smitt; J.M.B.V. de Jong; D. Troost This review concerns the immunohistochemical localization of metallothionein (MT), a metal-binding protein, in the mammalian central nervous system (CNS). Expression of MT in the mammalian CNS is abundant. In the mouse brain, MT...

... are familial and these have been linked to point mutations in the gene coding for cytosolic copper, zinc superoxide dismutase. The etiology of sporadic ALS is unknown. To further investigate the possible role of metals in causing the disease, we investigated metallothionein (MT) levels in ALS organs and serum...

...Keiji Suzuki; Katsuyuki Nakajima; Noriko Otaki; Masami Kimura Localization of metallothionein (MT) in the developing human brain was investigated by immunohistochemical techniques. Fetal brain at 21 weeks showed no MT expression. In 35-week-old fetuses, glial cells in the gray matter showed MT...

...M. Ebadi; M.A. Elsayed; M. Hamdy M. Aly By providing zinc, metallothionein is able to regulate cell division, differentiation, metabolism, signal transduction, and transmission of genetic information. 30 9 1994 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer...

...Kiyofumi Saijoh; Hironobu Katsuyama; Kimiaki Sumino Metallothionein (MT) gene expression in the brain has been most thoroughly studied using rodents. Although MT is considered to be a ''housekeeping'' protein even in the brain, the basal MT mRNA expression level is not always high. Differences...

...Jun-ichi Sawada; Yutaka Kikuchi; Makoto Shibutani; Kunitoshi Mitsumori; Kazuhide Inoue; Tadashi Kasahara Immunohistochemical staining of human and rat brains for metallothionein (MT) using a monoclonal anti-MT antibody (MT45) revealed that protoplasmic astrocytes, which are densely localized...

...John K. Young The metal-binding protein, metallothionein (MT) has been found to be primarily produced by astrocytes in the rat and human brain. This review discusses the relationship of glial MT to the distribution of metals in the brain, possible roles of MT in the regulation of glial enzymes...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Metallothionein Antisense oligonucleotide Phosphorothiotate oligonucleotide Chang liver cells V79 cells Biol...

...Patrick L. Iversen; John E. Mata; Manuchair Ebadi The metallothionein II gene, whose structure is highly conserved throughout the animal kingdom, is composed of three exons and two introns. Synthetic antisense oligonucleotides (ODN), with sequence complementary to the messenger RNA coding for human...

...Patrick L. Iversen; Manuchair Ebadi A synthetic antisense oligodeoxyribonucleotide with sequence complementary to the messenger RNA (mRNA) coding for human metallothionein (MT) II was prepared and tested for its ability to inhibit both constitutive- and cadmium-induced MT protein synthesis...