... is a critical regulator of hippocampal cell morphology. FAK mediated neurotrophin-induced neuritic outgrowth and FAK inhibition affected both miniature excitatory postsynaptic potentials and activity-dependent hippocampal long-term potentiation prompting us to explore the possible role of FAK in spatial...

...Wenchao Zhao; Xiaomei Wu; Hui Xie; Ya Ke; Wing-Ho Yung Many studies indicate that impairment in insulin signaling leads to learning and memory deficits. However, previous studies failed to establish a clear role of insulin in long-term potentiation (LTP), the best cellular model of memory formation...

... encountered hypoxia either once (H1) or 4 times (H4). Neural cell adhesion molecule (NCAM) expression, long-term potentiation (LTP) recording and Morris water maze test were used to measure the animals’ cognitive ability. The tolerance time was progressively prolonged as exposure went on. The expression...

...Jianxiong Jiang; Vishnu Suppiramaniam; Marie W. Wooten AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission in the mammalian brain. It is widely believed that the long-lasting, activity-dependent changes in synaptic strength, including long-term potentiation...

...: January 11, 2007 Structure and Function of PICK1 Junyu Xu Jun Xia Department of Biochemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, SAR, China Key Words PICK1 PDZ domain BAR domain Protein trafficking AMPA receptor Long-term potentiation Long-term depression...

... Biologic Mechanisms of Memory, Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Göttingen, Germany Key Words Cyclin-dependent kinase 5 W Hippocampus W Septum W Fear conditioning W Long-term potentiation W Sp transcription factors Abstract Learning and memory...