...Kenneth R. Watterson; Dawn Bestow; Jennifer Gallagher; D. Lee Hamilton; Fiona B. Ashford; Paul J. Meakin; Michael L.J. Ashford Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated...

... stress. However, all three agents impaired insulin receptor substrate-1 and Akt phosphorylation in the insulin signaling pathway. Ectopic overexpression of mitochondrial transcription factor A reversed the effects of thapsigargin on mitochondria and Akt signaling. We conclude that ER stress induces...

...Wenchao Zhao; Xiaomei Wu; Hui Xie; Ya Ke; Wing-Ho Yung Many studies indicate that impairment in insulin signaling leads to learning and memory deficits. However, previous studies failed to establish a clear role of insulin in long-term potentiation (LTP), the best cellular model of memory formation...

...Nitsa Mirsky; Israela Berdicevsky Addition of mammalian insulin or glucose tolerance factor (GTF), to Saccharomyces cerevisiae ATCC 7752, increased 2-deoxyglucose uptake by yeast cells. The enhancement was dose-dependent, and also dependent on preincubation of the cells with glucose, prior...