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Keywords: Depolarization
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Journal Articles

Tumour Necrosis Factor Induced an Early Release of Superoxide and a Late Mitochondrial Membrane Depolarization in L929 Cells : Increase in the Production of Superoxide Is Not Sufficient to Mimic the Action of TNF

Subject Area:
Neurology and Neuroscience
Samuel Ko, T.T. Kwok, K.P. Fung, Y.M. Choy, C.Y. Lee, S.K. Kong
Journal: Neurosignals
Biological Signals and Receptors (2001) 10 (5): 326–335.
https://doi.org/10.1159/000046900
Published Online: 07 August 2001
... in the production of O 2 – ·. The use of mitochondrial electron transport chain inhibitors such as antimycin A and rotenone could, respectively, potentiate or suppress the TNF-mediated release of O 2 – · and cytotoxicity. TNF also induced a late (>3 h after the addition of TNF) depolarization in the ΔΨm...
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