... Institute San Raffaele, Milan, Italy Key Words G proteins Go Mitogen-activated protein kinase Rap1 Cell growth Cell type differentiation Abstract Receptors coupled to Gi/o proteins stimulate the mitogenactivated protein kinase (MAPK) cascade. The intracellular pathways linking the chains...

... and posttranscriptional levels. In general, factors related to cell growth and differentiation operate on the gene transcription level, whereas iron regulates the fate of the mature mRNA. 19 6 1998 1998 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

...Margaret E. Tome; Eugene W. Gerner The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell...

... and insulin in a dose-dependent manner, whereas addition of ferric citrate could not reverse cell growth. Generation of the calcium signal probably reflects the initiation of the cell activation processes which could culminate into mitogenesis. Hence, our results suggest that apotransferrin, not iron...