... Cytoskeleton Exocytosis Autophagy Apoptosis Lack of functional chorein, a protein encoded by VPS13A (vacuolar protein sorting-associated protein 13A) [ 1 ], is the molecular basis of chorea-acanthocytosis (ChAc) [ 2-8 ], a progressive autosomal recessive neurodegenerative disease causing a complex...

... of misfolded proteins or injured mitochondria via autophagy has been reported to have neuroprotective roles in PD models. The fact that resveratrol is a known compound with multiple beneficial effects similar to those associated with energy metabolism led us to explore whether neuroprotective effects...

... targeted for degradation. The 2 principal routes of intracellular protein catabolism are the ubiquitin proteasome system and the autophagy-lysosome system (autophagy). Both of these degradation pathways have been implicated as playing important roles in the pathogenesis of neurodegenerative disease. Here...