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Keywords: Apoptosis
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Journal Articles
Neurosignals (2018) 25 (1): 117–126.
Published Online: 28 November 2017
... ]. Accordingly, ORAI [ 56 ] and STIM [ 57 ] isoforms participate in the orchestration of survival, proliferation, and migration of tumor cells [ 70-73 ] and neural stem/progenitor cells [ 74 ]. In contrast to Ca 2+ oscillations, sustained [Ca 2+ ] i increases trigger apoptosis [ 42-44 ]. Neurons generated...
Journal Articles
Neurosignals (2011) 19 (1): 1–15.
Published Online: 23 March 2011
..., the identification of LRRK2 interaction partners and kinase substrates and the generation of LRRK2 animal models. In this review, the current insights into the cellular role of LRRK2 are discussed. The overview reveals a potential involvement of LRRK2 in major cell signalling pathways including apoptosis...
Journal Articles
Journal Articles
Neurosignals (2006) 15 (2): 64–73.
Published Online: 18 July 2006
... of the dentate gyrus were also strongly labeled. In contrast, CA2 pyramidal cells were only weakly stained, and neurons of the molecular layer were unlabeled. Weak caspase-3 immunoreaction of CA2 neurons parallels known decreased susceptibility to apoptosis. In the cerebellar cortex, clusters of strongly labeled...
Journal Articles
Neurosignals (2006) 15 (1): 1–12.
Published Online: 04 July 2006
... of Biological Sciences, Nanyang Technological University, Singapore, and bMedical Center for Translational Research, Osaka University Hospital, Suita, Osaka, Japan Key Words Alzheimer s disease Apoptosis Nerve growth factor Neurodegeneration Neurotrophin Neural stem cells Abstract The protein family...
Journal Articles
Journal Articles
Neurosignals (2005) 14 (1-2): 71–82.
Published Online: 10 June 2005
... against hydrogen peroxide, β-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53 and caspase-3, protect...
Journal Articles
Journal Articles
Biological Signals and Receptors (2001) 10 (3-4): 189–199.
Published Online: 24 May 2001
... serious in mitochondria, because mitochondria in most cells lack catalase. Therefore, the excessive production of hydrogen peroxide in mitochondria will damage lipid, proteins and mDNA, which can then cause cells to die of necrosis or apoptosis. In order to study the important role of mitochondrial...
Journal Articles
Biological Signals and Receptors (2001) 10 (3-4): 147–161.
Published Online: 24 May 2001
...Roberta A. Gottlieb Apoptosis is a coordinated sequence of events culminating in the death of the cell. Many of these biochemical processes are regulated by the mitochondria, including the release of proapoptotic molecules in addition to the caspase-activating cofactor, cytochrome c. Pro...
Journal Articles
Biological Signals and Receptors (2001) 10 (3-4): 224–253.
Published Online: 24 May 2001
... L. Pellett R. Schafer C. Albano Josh Eken Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, N.Dak., USA Key Words Apoptosis W Dopaminergic neurons W Ubiquinone W Ubiquinol W Complex I W Mitochondria W Parkinson s...
Journal Articles
Biological Signals and Receptors (2001) 10 (3-4): 200–223.
Published Online: 24 May 2001
...Pál Pacher; György Csordás; György Hajnóczky The broad significance of apoptosis in the cardiovascular system only began to be recognized more widely recently. Apoptotic cell death is a normal component of postnatal morphogenesis of the human cardiac conduction system and may also be involved...
Journal Articles
Biological Signals and Receptors (2001) 10 (1-2): 81–92.
Published Online: 28 February 2001
... for the release of cytochrome c by lipid hydroperoxide has also been proposed. Mitochondria Apoptosis Glutathione peroxidase Cardiolipin hydroperoxide Cytochrome c © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...
Journal Articles
Biological Signals and Receptors (2001) 10 (1-2): 57–65.
Published Online: 28 February 2001
... Stress and Apoptosis Pedram Ghafourifara Urs Bringoldb Sabine D. Kleinb Christoph Richterb aDepartment of Medicine, University of Massachusetts Medical School, Worcester, Mass., USA; bInstitute of Biochemistry, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland Key Words Nitric oxide W...
Journal Articles
Biological Signals and Receptors (2001) 10 (1-2): 26–56.
Published Online: 28 February 2001
...Takashi Wakabayashi; Mariusz Karbowski The original concept of apoptosis stressed the morphological changes of the nucleus, condensation with the aggregation of chromatin, and the intactness of intracellular organelles including mitochondria. However, the application of molecular biology and flow...
Journal Articles
Biological Signals and Receptors (2000) 9 (2): 81–86.
Published Online: 10 May 2000
...Elizabeth A. McGee Less than 1% of ovarian follicles ever mature to ovulation. The remainder undergo atretic degeneration via apoptosis during development. Though the regulation of antral and preovulatory survival has been studied for many years, very little is known about the regulation...
Journal Articles
Biological Signals and Receptors (2000) 9 (2): 87–95.
Published Online: 10 May 2000
.... Apoptosis Ovary Granulosa cells FSH LH Inhibitor of apoptosis proteins TNF-α Fas/FasL Caspases p53 Biol Signals Recept 2000;9:87 95 Mammalian Follicular Development and Atresia: Role of Apoptosis Eric Asselin Chao Wu Xiao Yi Fang Wang Benjamin K. Tsang Reproductive Biology Unit and Division...
Journal Articles
Biological Signals and Receptors (2000) 9 (2): 96–101.
Published Online: 10 May 2000
...A.L. Johnson Ovarian follicle atresia in all vertebrates studied to date is mediated via apoptosis, a process that is often initiated within the granulosa cell layer. While follicle atresia is considered a normal physiological process to insure the greatest chance for ovulation of fertilizable...
Journal Articles
Biological Signals and Receptors (2000) 9 (2): 122–130.
Published Online: 10 May 2000
...Julang Li; Hiromasa Sasaki; Ying Lun Sheng; Danielle Schneiderman; Chao Wu Xiao; Fumikazu Kotsuji; Benjamin K. Tsang Cisplatin-induced apoptosis in epithelial ovarian cancer cells is in part a consequence of suppressed Xiap expression and upregulation of the Fas/FasL system. Changes...
Journal Articles
Biological Signals and Receptors (2000) 9 (2): 102–114.
Published Online: 10 May 2000
...William J. Murdoch Collagen breakdown and cellular death (apoptosis and inflammatory necrosis) within the apex of preovulatory ovine follicles are hallmarks of impending ovarian rupture. An integrative mechanism is presented whereby gonadotropic stimulation of urokinase-type plasminogen activator...