... Cytoskeleton Exocytosis Autophagy Apoptosis Chorein is at least partially effective by binding to phosphatidylinositol lipids [ 38 ]. In yeast binding of Vps13 proteins to phosphatidylinositol lipids of the cell membrane provides membrane contact sites and contributes to the steering of vesicle...

..., the identification of LRRK2 interaction partners and kinase substrates and the generation of LRRK2 animal models. In this review, the current insights into the cellular role of LRRK2 are discussed. The overview reveals a potential involvement of LRRK2 in major cell signalling pathways including apoptosis...

... neurotoxicity Neuroprotection Apoptosis Neuroglobin Estrogen receptor Original Paper Neurosignals 2010;18:223 235 DOI: 10.1159/000323906 Received: November 17, 2010 Accepted: December 28, 2010 Published online: February 18, 2011 17 -Estradiol A New Modulator of Neuroglobin Levels in Neurons: Role...

... of the dentate gyrus were also strongly labeled. In contrast, CA2 pyramidal cells were only weakly stained, and neurons of the molecular layer were unlabeled. Weak caspase-3 immunoreaction of CA2 neurons parallels known decreased susceptibility to apoptosis. In the cerebellar cortex, clusters of strongly labeled...

..., instructions or products referred to in the content or advertisements. Alzheimer’s disease Apoptosis Nerve growth factor Neurodegeneration Neurotrophin Neural stem cells Review Neurosignals 2006 07;15:1 12 DOI: 10.1159/000094383 Received: February 28, 2006 Accepted after revision: March 27, 2006...

... be correlated with Bcl-2 overexpression and enhanced stability of MMP, which ultimately reduces apoptosis 24 h after reoxygenation. 30 09 2004 6 01 2005 29 7 2005 © 2005 S. Karger AG, Basel 2005 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... against hydrogen peroxide, β-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53 and caspase-3, protect...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Tumour necrosis factor Mitochondria Mitochondrial membrane potential Depolarization Superoxide Apoptosis Original...

... serious in mitochondria, because mitochondria in most cells lack catalase. Therefore, the excessive production of hydrogen peroxide in mitochondria will damage lipid, proteins and mDNA, which can then cause cells to die of necrosis or apoptosis. In order to study the important role of mitochondrial...

...Roberta A. Gottlieb Apoptosis is a coordinated sequence of events culminating in the death of the cell. Many of these biochemical processes are regulated by the mitochondria, including the release of proapoptotic molecules in addition to the caspase-activating cofactor, cytochrome c. Pro...

... with Parkinson’s disease, CoQ 10 is able to attenuate the MPTP-induced loss of striatal dopaminergic neurons. 24 5 2001 Apoptosis Dopaminergic neurons Ubiquinone Ubiquinol Complex I Mitochondria Parkinson’s disease © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage / Disclaimer...

...Pál Pacher; György Csordás; György Hajnóczky The broad significance of apoptosis in the cardiovascular system only began to be recognized more widely recently. Apoptotic cell death is a normal component of postnatal morphogenesis of the human cardiac conduction system and may also be involved...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mitochondria Apoptosis Glutathione peroxidase Cardiolipin hydroperoxide Cytochrome c Biol Signals Recept 2001;10...

... 2001 Nitric oxide Peroxynitrite Mitochondria Nitric oxide synthase, mitochondrial Apoptosis Ca 2+ Respiration Cytochrome c Biol Signals Recept 2001;10:57 65 Mitochondrial Nitric Oxide Synthase, Oxidative Stress and Apoptosis Pedram Ghafourifara Urs Bringoldb Sabine D. Kleinb Christoph...

...Takashi Wakabayashi; Mariusz Karbowski The original concept of apoptosis stressed the morphological changes of the nucleus, condensation with the aggregation of chromatin, and the intactness of intracellular organelles including mitochondria. However, the application of molecular biology and flow...

...Elizabeth A. McGee Less than 1% of ovarian follicles ever mature to ovulation. The remainder undergo atretic degeneration via apoptosis during development. Though the regulation of antral and preovulatory survival has been studied for many years, very little is known about the regulation...

.... Apoptosis Ovary Granulosa cells FSH LH Inhibitor of apoptosis proteins TNF-α Fas/FasL Caspases p53 Biol Signals Recept 2000;9:87 95 Mammalian Follicular Development and Atresia: Role of Apoptosis Eric Asselin Chao Wu Xiao Yi Fang Wang Benjamin K. Tsang Reproductive Biology Unit and Division...

...A.L. Johnson Ovarian follicle atresia in all vertebrates studied to date is mediated via apoptosis, a process that is often initiated within the granulosa cell layer. While follicle atresia is considered a normal physiological process to insure the greatest chance for ovulation of fertilizable...

...Julang Li; Hiromasa Sasaki; Ying Lun Sheng; Danielle Schneiderman; Chao Wu Xiao; Fumikazu Kotsuji; Benjamin K. Tsang Cisplatin-induced apoptosis in epithelial ovarian cancer cells is in part a consequence of suppressed Xiap expression and upregulation of the Fas/FasL system. Changes...

...William J. Murdoch Collagen breakdown and cellular death (apoptosis and inflammatory necrosis) within the apex of preovulatory ovine follicles are hallmarks of impending ovarian rupture. An integrative mechanism is presented whereby gonadotropic stimulation of urokinase-type plasminogen activator...