... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Metallothionein Antisense oligonucleotide Phosphorothiotate oligonucleotide Chang liver cells V79 cells Biol...

...Patrick L. Iversen; John E. Mata; Manuchair Ebadi The metallothionein II gene, whose structure is highly conserved throughout the animal kingdom, is composed of three exons and two introns. Synthetic antisense oligonucleotides (ODN), with sequence complementary to the messenger RNA coding for human...

... to be associated with cells. The antisense oligonucleotide inhibition of MT protein synthesis rendered both cell types more sensitive to cadmium toxicity. However, the sense oligonucleotide had no effects on either MT protein synthesis or sensitivity to cadmium toxicity. 25 3 1992 © 1992 S. Karger AG...