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Keywords: Alzheimer’s disease
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Journal Articles
Neurosignals (2016) 24 (1): 95–101.
Published Online: 24 October 2016
...Zijuan Zhang; Meixia Guo; Juan Zhang; Caixia Du; Ying Xing Background/Aims: Leptin, an adipocytokine produced endogenously in the brain, is decreased in Alzheimer's disease(AD) and has also been shown to reduce Aβ levels in vitro and in vivo . Sets of evidence show that leptin reduces Aβ production...
Journal Articles
Journal Articles
Neurosignals (2009) 17 (1): 23–41.
Published Online: 12 February 2009
.... G protein Go G-protein-coupled receptors Signal transduction Effectors Central nervous system Alzheimer’s disease National Institutes of Health (NIH) 10.13039/100000002 Invited Review Neurosignals 2009;17:23 41 DOI: 10.1159/000186688 Received: March 14, 2008 Accepted after...
Journal Articles
Neurosignals (2007) 16 (1): 91–98.
Published Online: 05 December 2007
...Jason Karlawish Cognitive and functional losses are only part of the spectrum of disability experienced by persons with Alzheimer’s disease and related dementias. They also experience losses in the ability to make decisions, known as decision-making capacity. Researchers have made substantial...
Journal Articles
Neurosignals (2007) 16 (1): 11–18.
Published Online: 05 December 2007
...C.M. Clark; C. Davatzikos; A. Borthakur; A. Newberg; S. Leight; V.M.-Y. Lee; J.Q. Trojanowski The increasing prevalence of Alzheimer’s disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated...
Journal Articles
Neurosignals (2007) 16 (1): 19–23.
Published Online: 05 December 2007
...Leslie M. Shaw There is a pressing need to develop effective prevention and disease-modifying treatments for Alzheimer’s disease (AD), a dreaded affliction whose incidence increases almost logarithmically with age starting at about 65 years. A key need in the field of AD research is the validation...
Journal Articles
Neurosignals (2007) 16 (1): 5–10.
Published Online: 05 December 2007
... on Aging, Center for Neurodegenerative Disease Research, Alzheimer Disease Core Center, Udall Parkinson s Research Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA Key Words Aging Alzheimer s disease Parkinson s disease...
Journal Articles
Neurosignals (2006) 15 (1): 1–12.
Published Online: 04 July 2006
... to their established functions for cell survival, NTs also mediate higher brain activities such as learning and memory. Changes in NT expression levels have thus been implicated in neurological diseases such as Alzheimer’s disease (AD), an age-related neurodegenerative disorder that is characterized by progressive...
Journal Articles
Neurosignals (2005) 14 (1-2): 34–45.
Published Online: 10 June 2005
.... In each compound, neurite outgrowth activity was investigated under amyloid-β-induced neuritic atrophy. Most of the compounds with neurite regenerative activity also demonstrated memory improvement activity in Alzheimer’s disease-model mice. Protopanaxadiol-type saponins in Ginseng drugs...
Journal Articles
Neurosignals (2005) 14 (1-2): 6–22.
Published Online: 10 June 2005
...Peter J. Houghton; Melanie-Jayne Howes The two major neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterised by low levels in the brain of the neurotransmitters acetylcholine (ACh) and dopamine (DA), respectively. Clinical treatment of these two conditions...
Journal Articles
Journal Articles
Neurosignals (2004) 13 (3): 134–143.
Published Online: 22 April 2004
...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cyclin-dependent kinase Glycogen synthase kinase GSK-3β Paullones Purines Kinase inhibitor Alzheimer’s disease...
Journal Articles
Neurosignals (2003) 12 (4-5): 209–214.
Published Online: 18 December 2003
...Lit-Fui Lau; Michael K. Ahlijanian Alzheimer’s disease (AD) is characterized by two pathological hallmarks, namely, senile plaques and neurofibrillary tangles (NFTs). The former are mainly composed of amyloid-β peptides (Aβ) while the latter consists mainly of filaments of hyperphosphorylated tau...
Journal Articles
Neurosignals (2003) 12 (4-5): 164–172.
Published Online: 18 December 2003
... and has been implicated in the development of neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis. In this review, we concentrate on the regulation of CDK5 activity, privileging a structural perspective based on a decade of structural analyses of different members...
Journal Articles
Neurosignals (2003) 12 (4-5): 215–220.
Published Online: 18 December 2003
... to decipher the mechanisms of neurodegeneration in amyotrophic lateral sclerosis induced by Cdk5. Cyclin-dependent kinase 5 Neurodegeneration Amyotrophic lateral sclerosis Cell cycle Cytoskeleton Alzheimer’s disease Review Neurosignals 2003;12:215 220 DOI: 10.1159/000074623 Received: April 10, 2003...
Journal Articles
Neurosignals (2002) 11 (5): 270–281.
Published Online: 21 January 2003
...Xiongwei Zhu; Hyoung-gon Lee; Arun K. Raina; George Perry; Mark A. Smith Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating cellular processes that are affected in Alzheimer’s disease (AD), the importance of MAPKs in disease pathogenesis is being increasingly...
Journal Articles
Journal Articles
Neurosignals (2002) 11 (5): 236–250.
Published Online: 21 January 2003
...Masaoki Kawasumi; Yuichi Hashimoto; Tomohiro Chiba; Kohsuke Kanekura; Yohichi Yamagishi; Miho Ishizaka; Hirohisa Tajima; Takako Niikura; Ikuo Nishimoto To develop a therapeutic intervention for Alzheimer’s disease (AD), it is necessary to clarify the mechanisms underlying the pathogenesis of AD...
Journal Articles
Neurosignals (2002) 11 (5): 262–269.
Published Online: 21 January 2003
...Qing Tian; Jianzhi Wang Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer’s disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD...
Journal Articles
Neurosignals (2002) 11 (4): 175–190.
Published Online: 18 October 2002
... to that in vascular smooth muscle cells. Although NO (at high concentrations) is toxic and thought to participate in neuronal cell death during stroke and neurodegenerative diseases (e.g. amyotrophic lateral sclerosis, Alzheimer’s disease, HIV dementia and Parkinson’s disease), recent evidence suggests that NO at low...