Although the cell nucleus is known to control much of cell function, little is known as to the mediator of such function. Recent evidence has suggested that Ca2+ may be responsible for the regulation of many nuclear events. Early investigations have reported that the nucleus may be able to control its calcium function independently of the adjacent cytosol. IP3 and IP4 may act as regulators of nuclear Ca2+ independently or in parallel with the cytosol. This paper examines the current state of knowledge regarding nuclear calcium regulation. Additionally, a model for this regulation is proposed.

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