...J.X. Thavundayil; R. Hambalek; N.M.K. Ng Ying Kin; B. Krishnan; S. Lal We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone...

...C.J. Ali; J.A. Henry The London Centre of the UK National Poisons Information Service has received 107 enquiries about cases of self-poisoning involving trazodone. In 46 cases further data concerning symptoms and outcome were received from the doctor who made the enquiry. The data so far received...

... are affected by it. An early diagnosis and a proper treatment are crucial problems. Because of the numerous side effects of tricyclic antidepressants, today we are able to use some third-generation antidepressants which show unquestionable advantages in the therapy of depression in the elderly. Trazodone...

... antidepressants may die, despite every medical effort to save him. An overdose of trazodone significantly differs from an overdose of a tricyclic antidepressant. The currently available clinical data indicate that coma and hypotension are the main concerns with trazodone overdose, and heretofore have been...

...Herbert Moskowitz; Marcelline M. Burns The effects of amitriptyline, trazodone and placebo on cognitive skills performance were examined in a group of 15 normal volunteers with a minimum age of 60. Each subject was behaviorally tested after single, acute treatments at weekly sessions using...

...C. Benkelfat; C. Gay; M. Renardet This study reports the efficacy and safety of trazodone as an antidepressant drug in a national telematic multicenter outpatient open clinical trial. In less than 3 months, 1,700 patients completed a 1-month treatment and among them, 65 % were considered...

...Bruno Silvestrini The mental pain hypothesis used to develop trazodone is illustrated, together with its medical and methodological implications. Trazodone possesses a well documented antidepressant activity, which indirectly confirms the above hypothesis. It lacks the aminergic effects of other...

...Hecht Orzack; Jonathan O. Cole; Loren Friedman; Michael Bird; John McEachern Weight data taken from a 6-week randomized double-blind study comparing amitriptyline, trazodone and placebo were analyzed to determine differential weight changes between the two drugs. In 272 depressed outpatients doses...

...Ashoka Prasad Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2...

... that block the reuptake of serotonin, such as trazodone and amitriptyline, are being studied. The rationale for the current hypothesis, including psychopharmacology and the role of serotonin reuptake blockers, will be reviewed. 20 2 2008 © 1986 S. Karger AG, Basel 1986 Copyright / Drug Dosage...

...S.J. Warrington; S.I. Ankier; P. Turner The pharmacodynamic effects of single doses of trazodone (100 mg), amitriptyline (50 mg) or placebo either alone or with ethanol (0.5 ml/kg) were investigated in 6 healthy volunteers in a double-blind crossover study. Plasma concentrations of the drugs...

...G. Roccatagliata; G. Murialdo; C. Albano; M. Giovale; C. Zauli; A. Polleri Prolactin and somatotropin secretory rhythmicity was studied in 7 inhibited depression male patients, evaluated by the Hamilton Rating Scale for depression, before and after trazodone (400 mg i.v. once daily) treatment...

...Z. Górka; Bernadette Earley; B.E. Leonard Bilaterally olfactory bulbectomized rats were compared with intact rats in their responsiveness to the acute and chronic administration of nomifensine and trazodone in the learned immobility test of Porsolt. No difference in the duration of immobility...

...E. Rolandi; G. Magnani; G.M. Milesi; T. Barreca Administration of 50 mg trazodone, an antidepressant drug, in a single oral dose to 10 normal subjects of both sexes, aged 24–41, resulted in a significant (p < 0.01) decrease of serum prolactin (PRL) values. The mean serum PRL levels were 8.9...

... of the acute effects of 100 mg of a controlled-release formulation of trazodone (Trittico ® retard) in the patients demonstrated an increase in the target variable SWS, accompanied by a reduction in the number of awakenings and stage shifts. It normalized the frequency of shifts from S2 to W and reduced...

...Gerda Maria Saletu-Zyhlarz; Peter Anderer; Oliver Arnold; Bernd Saletu Early human pharmaco-EEG and subsequent sleep laboratory studies identified trazodone, a 5-HT 2 antagonist and 5-HT reuptake inhibitor (SARI), as an antidepressant with therapeutic effects on its target symptoms depressed mood...

... measures showed deteriorated numerical memory, fine motor activity and reaction time variability. In a placebo-controlled crossover design study, the acute effects of 100 mg trazodone 1 , a serotonin reuptake inhibitor with a sedative action due to 5HT 2 and α 1 receptor blockade, were investigated...

...Satoshi Hatsuda; Sotaro Sugita; Shigeru Suzuki; Momoyo Matsubara; Norio Ozaki; Yuhei Kayukawa; Mitsugi Ohara Using microdialysis, extracellular concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined in the striatum of rats. In rats given trazodone, m...

... improvement was observed. Reasons for this discrepancy will be discussed. Novel 5-HT reuptake inhibitors with additional modes of action such as 5-HT2 antagonism (e.g. trazodone, nefazodone) are more likely to improve objective and subjective sleep quality, although some shortcomings may be inherent in regard...