...Ali Bani-Fatemi; Christopher Adanty; Nasia Dai; Ariel Graff; Philip Gerretsen; Vincenzo De Luca Background: Studies have shown that the overall copy number variant (CNV) load is associated with schizophrenia. Schizophrenia is a mental disorder that is frequently associated with suicidal behavior...

...Paul Jeffrey Schwartz Purpose: Seattle-inspired rock and roll superstar Chris Cornell died by suicide in May 2017. In the northern hemisphere, May represents the peak of the widely replicated but still unexplained seasonal spring rhythm in suicide. Years earlier, Cornell had suffered openly from...

... concentrations of L-tryptophan (TRY) and increased L-kynurenine (KYN), or its metabolites, in the body fluids of subjects with major depressive disorder (MDD), sometimes in association with suicidal behavior. Such changes might indicate a shift of TRY away from serotonin production, possibly via the effects...

... of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. Methods: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275...

...Mohammad Ahmadpanah; Amir Hosein Rahighi; Mohammad Haghighi Background: Self-immolation (SI) is considered one of the most painful, dramatic, and at the same time most inexplicable methods of suicide, with a high social impact. Prevalence rates are particularly high in Iran, and in north-western...

...Ali Bani-Fatemi; Aaron Howe; Clement Zai; James L. Kennedy; John Vincent; John Strauss; Albert Wong; Vincenzo De Luca Objectives: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. Methods...

...Livia Ambrus; Charlotta Sunnqvist; Rolf Ekman; Lil Träskman-Bendz; Åsa Westrin Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms...

...Ali Bani-Fatemi; Aaron S. Howe; Michelle Matmari; Arthur Koga; Clement Zai; John Strauss; Vincenzo De Luca Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes...

...Liliana Dell'Osso; Laura Mandelli; Marina Carlini; Siham Bouanani; Alessandro Rotondo; Ciro Conversano; Alessandro Serretti; Donatella Marazziti Background and Aims: Literature findings mainly support the notion that suicide attempts (SA) and self-mutilating behavior (SMB) are distinct behaviors...

...Tuomo Karhumaa; Helinä Hakko; Rauno Nauha; Pirkko Räsänen Background: Season of birth is associated with several psychiatric disorders and suicidal behavior. We explored the association between the season of birth and suicide among schizophrenic and psychotic suicide victims. Methods: The study...

...Félicien Karege; Nader Perroud; Sandra Burkhardt; Rafael Fernandez; Eladia Ballmann; Romano La Harpe; Alain Malafosse Background: Recent studies have reported alterations in protein kinase B (PKB)/Akt and in its downstream target, glycogen synthase kinase 3β, in depression and suicide. The aim...

...Hwa-Young Lee; Yong-Ku Kim Genetic factors and catecholaminergic dysfunction have been suggested as the etiology of suicide. The catechol- O -methyltransferase (COMT) 158Val/Met polymorphism affects COMT activity; that is, the alleles encoding Val and Met are associated with relatively high...

...M. Mercedes Perez-Rodriguez; Jorge Lopez-Castroman; Maria Martinez-Vigo; Carmen Diaz-Sastre; Antonio Ceverino; Amparo Núñez-Beltrán; Jeronimo Saiz-Ruiz; Jose de Leon; Enrique Baca-Garcia Objective: To determine whether testosterone levels differ in male suicide attempters versus healthy controls...

... the otherwise 2- to 3-fold increased mortality of untreated patients with severe affective disorders down to the level of the general population. This is mainly due to the reduced suicide risk. Many international studies have confirmed this fascinating property of lithium which so far has not been demonstrated...

... comparisons of clinical features were performed without a priori knowledge of the genotype of individual patients. Results: Allelic distributions did not differ significantly between bipolar patients and controls (χ 2 = 0.400, p = 0.821). However, the rate of suicide attempts among the Val/Val (11.3%), Val...

...Marco Sarchiapone; Vladimir Carli; Alec Roy; Licia Iacoviello; Chiara Cuomo; Maria Carmela Latella; Massimo di Giannantonio; Luigi Janiri; Monica de Gaetano; Malvin N. Janal Introduction: Recent post-mortem studies of suicide victims have implicated brain-derived neurotrophic factor (BDNF...

...Michel Hansenne; William Pitchot; Antonio Gonzalez Moreno; Jose Gonzalez Torrecilas; Jean Mirel; Marc Ansseau P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results show a significant reduction of both P300...

...Ingrid Sundman; Per Allard; Anders Eriksson; Jan Marcusson The binding of [ 3 H]nipecotic acid to GABA uptake sites was studied in post mortem human frontal cortex from 17 suicide victims and 21 controls without known neurological or psychiatric disorder. The suicide victims were subclassified...

...Michael J. Garvey; Steven D. Hollon; V.B. Tuason Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness...

...Alec Roy Neuropeptides were examined in relation to suicidal behavior and its repetition in depression. There were no significant differences between depressed patients who had or had not attempted suicide for cerebrospinal fluid (CSF) concentrations of neuropeptide Y, somatostatin, diazepam...