... of this drug combination. The present study investigated the development of locomotor sensitization in laboratory rats given 7 once-weekly exposures to either MDMA, GHB or their combination (MDMA/GHB). The drugs were administered at a high ambient temperature (28°C) to mimic nightclub conditions. MDMA (5 mg/kg...

...Yn-Ho Huang; Shih-Jen Tsai; Ying-Chou Wang; Meng-Fen Yu; Yu-Chih Yang; Cho-Boon Sim Behavioral sensitization elicited by repeated administration of amphetamine does not fully develop until a period after discontinuation of amphetamine, but then persists undiminished for a long time. This experiment...

...Yn-Ho Huang; Shih-Jen Tsai; Meng-Fen Yu; Ying-Chou Wang; Yu-Chih Yang; Cho-Boon Sim The daily dose of amphetamine pretreatment may affect the development of behavioral-sensitized patterns in rodents and amphetamine psychosis in humans. This experiment investigated the regional cerebral metabolic...

... changes contribute to the enduring synaptic plasticity that underlies sensitized responses to psychostimulants and drug-conditioned memories leading to compulsive drug use and frequent relapse after withdrawal. Nevertheless, increased BDNF levels could also have a role as a protection factor in addiction...