.... This study explores inflammation-related mediators as potential biomarkers for CUD and dual diagnosis with schizophrenia (SCZ) or antisocial personality disorder (APD). Methods: This exploratory study included 95 participants, comprising 40 healthy subjects and 55 abstinent patients with CUD. Lifetime CUD...

... criteria for schizophrenia. Given his overall clinical picture, chromosomal microarray analysis was completed, which revealed a 19.78 Mb deletion at 18q21.32 from nucleotide 58,226,713 to 78,015,180 (GRCh37). Despite exhibiting a somewhat idiosyncratic response to numerous antipsychotic medications, he...

...Vincenzo De Luca; Zanib Chaudhary; Nzaar Al-Chalabi; Jessica Qian; Xiaoguang Xu; Philip Gerretsen; Ali Bani-Fatemi; Alexander Simpson; Corinne Fischer; Ariel Graff; Nathan J. Kolla Introduction: An increased proclivity towards violence is often associated with those diagnosed with schizophrenia...

...Mark Ainsley Colijn 3q29 deletion syndrome is characterized by various developmental abnormalities, medical issues, and neuropsychiatric symptoms, including psychosis. Although this syndrome may confer the greatest risk for schizophrenia of any copy number variation, response to antipsychotic...

... on these waveforms as potential biomarkers for schizophrenia. Methods: MMN and P3a were elicited with a novelty paradigm using complex stimuli with electrophysiological technology. Results: No significant group differences of amplitude were observed with either waveform. Increased asociality and blunted affect were...

...Handan Noyan; Andac Hamamci; Zeynep Firat; Aysegul Sarsilmaz; Alp Ucok Introduction: Different influences of ovarian hormones in schizophrenia (SCZ) have been reported, but no study to date has assessed their effects on the brain dynamics at rest. The present study aimed to examine the hormonal...

...Kasumi Yasuda; Shinichi Yamada; Shinya Uenishi; Natsuko Ikeda; Atsushi Tamaki; Yuji Ohoshi; Tomikimi Tsuji; Shun Takahashi Introduction: The hippocampus is relevant to cognitive function in schizophrenia (SCZ) and mood disorder patients. Although not anatomically uniform, it is clearly divided...

...Claudia Cornelis; Livia J. De Picker; Violette Coppens; Anne Morsel; Maarten Timmers; Glenn Dumont; Bernard G.C. Sabbe; Manuel Morrens; Wouter Hulstijn Background: The “cognitive dysmetria hypothesis” of schizophrenia proposes a disrupted communication between the cerebellum and cerebral cortex...

...Margarita A. Morozova; Tatyana V. Lezheiko; Taissia A. Lepilkina; Denis S. Burminskiy; Sergey S. Potanin; Allan G. Beniashvili; George E. Rupchev; Vera E. Golimbet Introduction: The pathophysiological mechanisms of acute schizophrenia are largely unknown, but it is widely accepted that dopamine D2...

... Antibodies Psychosis Schizophrenia Autoimmune encephalitis Despite the promise associated with the discovery of a link between general paresis and syphilis in the late 1880s, further attempts to determine the etiology of mental disorders have been largely unsuccessful. New hope arose in 2007 when...

...Anthony O. Ahmed; Samantha Kramer; Naama Hofman; John Flynn; Marie Hansen; Victoria Martin; Anilkumar Pillai; Peter F. Buckley Aim: The Val66Met single-nucleotide polymorphism (SNP) on the BDNF gene has established pleiotropic effects on schizophrenia incidence and morphologic alterations...

...Ali Bani-Fatemi; Christopher Adanty; Nasia Dai; Ariel Graff; Philip Gerretsen; Vincenzo De Luca Background: Studies have shown that the overall copy number variant (CNV) load is associated with schizophrenia. Schizophrenia is a mental disorder that is frequently associated with suicidal behavior...

...Ana Elisa Rodríguez-Martínez; Nancy Monroy-Jaramillo; Yaneth Rodríguez-Agudelo; Rodolfo Solís-Vivanco Introduction: Although working memory (WM) dysfunction has been proposed as a schizophrenia (SZ) endophenotype, the specific impaired component (encoding or maintenance) in patients and unaffected...

... of schizophrenic psychosis. Therefore, we investigated whether consumption of cannabis has an impact on the methylation pattern of schizophrenia candidate genes concerned with the development and preservation of synapses and synaptic function. Methods: Fifty blood samples of outpatients affected by treatment...

.... This results in a high percentage of misdiagnosis and consequential inefficient treatment; especially regarding major depressive disorder (MDD), depression in the context of bipolar disorder (BD-D), bipolar disorder with manic symptoms (BD-M), and psychosis in the context of schizophrenia (SZ). Objective...

... for morphologic abnormalities and symptoms in patients suffering from schizophrenia. Objective: The main goal of this research was to investigate the interrelationship between vitamin D, nerve growth factors (NGF, brain-derived neurotrophic factor [BDNF], and neuregulin-1 [NRG1]), and schizophrenia symptom...

... modification of the relative incidence of major depressive disorder (MDD) ( F 11, 72 = 2.898; p = 0.003; eta-squared, ES = 0.313; ⍺ = 0.97), anxiety-related disorder (ARD) ( F 11, 81 = 2.389; p = 0.013; ES = 0.241; ⍺ = 0.932), and schizophrenia (SZ) ( F 11, 83 = 2.764; p = 0.005; ES = 0.303; α = 0.963), while...

...Taylor Marzouk; Stephanie Winkelbeiner; Heela Azizi; Anil K. Malhotra; Philipp Homan Transcranial magnetic stimulation (TMS) has been proposed as a potential treatment add-on for positive symptoms in schizophrenia. To summarize the current evidence for its efficacy, we reviewed clinical trials from...

... cerebral blood flow Schizophrenia Endogenous psychoses At the turn of the century, doubt emerged about the DSM research program initiated 2 decades earlier with its third version. This triggered a surge of creative thinking ending with the proposal of many alternatives such as DSM-5 section 3 [ 1...

...Gaini Ma; Xiaoye Huang; Yan Bi; Fei Xu; Weibo Niu; Decheng Ren; Qianqian Sun; Zhenming Guo; Ruixue Yuan; Fan Yuan; Xi Wu; Fengping Yang; Lu Wang; Weidong Li; Lin He; Tao Yu; Xingwang Li; Jie Liu; Guang He Background: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder...